Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum

Top-down proteomics can provide unique insights into the biological variations of protein biomarkers but detecting low-abundance proteins in body fluids remains challenging. Here, the authors develop a nanoparticle-based top-down proteomics approach enabling enrichment and detailed analysis of cardi...

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Autores principales:	Timothy N. Tiambeng, David S. Roberts, Kyle A. Brown, Yanlong Zhu, Bifan Chen, Zhijie Wu, Stanford D. Mitchell, Tania M. Guardado-Alvarez, Song Jin, Ying Ge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0c9fa14088c495f99c147d838fbac0d
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spelling	oai:doaj.org-article:f0c9fa14088c495f99c147d838fbac0d2021-12-02T14:53:51ZNanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum10.1038/s41467-020-17643-12041-1723https://doaj.org/article/f0c9fa14088c495f99c147d838fbac0d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17643-1https://doaj.org/toc/2041-1723Top-down proteomics can provide unique insights into the biological variations of protein biomarkers but detecting low-abundance proteins in body fluids remains challenging. Here, the authors develop a nanoparticle-based top-down proteomics approach enabling enrichment and detailed analysis of cardiac troponin I in human serum.Timothy N. TiambengDavid S. RobertsKyle A. BrownYanlong ZhuBifan ChenZhijie WuStanford D. MitchellTania M. Guardado-AlvarezSong JinYing GeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Timothy N. Tiambeng David S. Roberts Kyle A. Brown Yanlong Zhu Bifan Chen Zhijie Wu Stanford D. Mitchell Tania M. Guardado-Alvarez Song Jin Ying Ge Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
description	Top-down proteomics can provide unique insights into the biological variations of protein biomarkers but detecting low-abundance proteins in body fluids remains challenging. Here, the authors develop a nanoparticle-based top-down proteomics approach enabling enrichment and detailed analysis of cardiac troponin I in human serum.
format	article
author	Timothy N. Tiambeng David S. Roberts Kyle A. Brown Yanlong Zhu Bifan Chen Zhijie Wu Stanford D. Mitchell Tania M. Guardado-Alvarez Song Jin Ying Ge
author_facet	Timothy N. Tiambeng David S. Roberts Kyle A. Brown Yanlong Zhu Bifan Chen Zhijie Wu Stanford D. Mitchell Tania M. Guardado-Alvarez Song Jin Ying Ge
author_sort	Timothy N. Tiambeng
title	Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
title_short	Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
title_full	Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
title_fullStr	Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
title_full_unstemmed	Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
title_sort	nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f0c9fa14088c495f99c147d838fbac0d
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Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum

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