Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo

The role of the transmembrane glycoprotein CD47 in healing injured intestinal mucosa is unclear. Here, the authors show that selective loss of CD47 in the murine intestinal epithelium results in defective mucosal repair after colonic wounding, with suggested impaired cell migration in vitro.

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Autores principales:	Michelle Reed, Anny-Claude Luissint, Veronica Azcutia, Shuling Fan, Monique N. O’Leary, Miguel Quiros, Jennifer Brazil, Asma Nusrat, Charles A. Parkos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0ca1f6c382d4838b22e30bc6b39240c
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spelling	oai:doaj.org-article:f0ca1f6c382d4838b22e30bc6b39240c2021-12-02T15:36:18ZEpithelial CD47 is critical for mucosal repair in the murine intestine in vivo10.1038/s41467-019-12968-y2041-1723https://doaj.org/article/f0ca1f6c382d4838b22e30bc6b39240c2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12968-yhttps://doaj.org/toc/2041-1723The role of the transmembrane glycoprotein CD47 in healing injured intestinal mucosa is unclear. Here, the authors show that selective loss of CD47 in the murine intestinal epithelium results in defective mucosal repair after colonic wounding, with suggested impaired cell migration in vitro.Michelle ReedAnny-Claude LuissintVeronica AzcutiaShuling FanMonique N. O’LearyMiguel QuirosJennifer BrazilAsma NusratCharles A. ParkosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michelle Reed Anny-Claude Luissint Veronica Azcutia Shuling Fan Monique N. O’Leary Miguel Quiros Jennifer Brazil Asma Nusrat Charles A. Parkos Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
description	The role of the transmembrane glycoprotein CD47 in healing injured intestinal mucosa is unclear. Here, the authors show that selective loss of CD47 in the murine intestinal epithelium results in defective mucosal repair after colonic wounding, with suggested impaired cell migration in vitro.
format	article
author	Michelle Reed Anny-Claude Luissint Veronica Azcutia Shuling Fan Monique N. O’Leary Miguel Quiros Jennifer Brazil Asma Nusrat Charles A. Parkos
author_facet	Michelle Reed Anny-Claude Luissint Veronica Azcutia Shuling Fan Monique N. O’Leary Miguel Quiros Jennifer Brazil Asma Nusrat Charles A. Parkos
author_sort	Michelle Reed
title	Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
title_short	Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
title_full	Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
title_fullStr	Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
title_full_unstemmed	Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
title_sort	epithelial cd47 is critical for mucosal repair in the murine intestine in vivo
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f0ca1f6c382d4838b22e30bc6b39240c
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Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo

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