Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
The role of the transmembrane glycoprotein CD47 in healing injured intestinal mucosa is unclear. Here, the authors show that selective loss of CD47 in the murine intestinal epithelium results in defective mucosal repair after colonic wounding, with suggested impaired cell migration in vitro.
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Main Authors: | Michelle Reed, Anny-Claude Luissint, Veronica Azcutia, Shuling Fan, Monique N. O’Leary, Miguel Quiros, Jennifer Brazil, Asma Nusrat, Charles A. Parkos |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2019
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Subjects: | |
Online Access: | https://doaj.org/article/f0ca1f6c382d4838b22e30bc6b39240c |
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