Gender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening

As an innate feature of human beings, gender differences have an influence on various biological phenotypes, yet it does not attract enough attention in genomics studies. The prognosis of multiple carcinomas usually exhibits a favorable ending for female patients, but the neglect of gender differenc...

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Autores principales:	Tao Yan, Kai Wang, Qidi Zhao, Junjie Zhuang, Hongchang Shen, Guoyuan Ma, Lei Cong, Jiajun Du
Formato:	article
Lenguaje:	EN
Publicado:	PeerJ Inc. 2021
Materias:	Gender eRNA Immunotherapy Lung squamous cell carcinoma Pan-cancer analysis Medicine R
Acceso en línea:	https://doaj.org/article/f0cdc809e27244219b1c2dca14e88eb2
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spelling	oai:doaj.org-article:f0cdc809e27244219b1c2dca14e88eb22021-11-27T15:05:10ZGender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening10.7717/peerj.125362167-8359https://doaj.org/article/f0cdc809e27244219b1c2dca14e88eb22021-11-01T00:00:00Zhttps://peerj.com/articles/12536.pdfhttps://peerj.com/articles/12536/https://doaj.org/toc/2167-8359As an innate feature of human beings, gender differences have an influence on various biological phenotypes, yet it does not attract enough attention in genomics studies. The prognosis of multiple carcinomas usually exhibits a favorable ending for female patients, but the neglect of gender differences can cause serious bias in survival analysis. Enhancer RNAs (eRNAs) are mostly downstream of androgens or estrogen. The present study was aimed to screen eRNAs in patients with non-small-cell lung cancer. The findings revealed that eRNA TBX5-AS1 was expressed differently between female and male patients. Meanwhile, its prognostic significance appeared only in male patients with squamous cell carcinoma (SCC) type. The Gene Set Enrichment Analysis proved that the expression level of TBX5-AS1 increased following the activation of the androgen signaling pathway. In pan-cancer analysis, the prognostic prediction based on gender grouping obtained more meaningful results, and the synergy between TBX5-AS1 and its homologous target was more consistent. Furthermore, immunity variations between sexes prompted us to explore the role that TBX5-AS1 played in tumor microenvironment and immunotherapy. The robust evidence proved that male patients with high expression of TBX5-AS1 possessed a malignant immune microenvironment and urgently needed immune checkpoint inhibitor treatment. In conclusion, TBX5-AS1 may be one of the strongest candidates to predict prognosis for male patients with SCC and provide a reference for immunotherapy.Tao YanKai WangQidi ZhaoJunjie ZhuangHongchang ShenGuoyuan MaLei CongJiajun DuPeerJ Inc.articleGendereRNAImmunotherapyLung squamous cell carcinomaPan-cancer analysisMedicineRENPeerJ, Vol 9, p e12536 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gender eRNA Immunotherapy Lung squamous cell carcinoma Pan-cancer analysis Medicine R
spellingShingle	Gender eRNA Immunotherapy Lung squamous cell carcinoma Pan-cancer analysis Medicine R Tao Yan Kai Wang Qidi Zhao Junjie Zhuang Hongchang Shen Guoyuan Ma Lei Cong Jiajun Du Gender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening
description	As an innate feature of human beings, gender differences have an influence on various biological phenotypes, yet it does not attract enough attention in genomics studies. The prognosis of multiple carcinomas usually exhibits a favorable ending for female patients, but the neglect of gender differences can cause serious bias in survival analysis. Enhancer RNAs (eRNAs) are mostly downstream of androgens or estrogen. The present study was aimed to screen eRNAs in patients with non-small-cell lung cancer. The findings revealed that eRNA TBX5-AS1 was expressed differently between female and male patients. Meanwhile, its prognostic significance appeared only in male patients with squamous cell carcinoma (SCC) type. The Gene Set Enrichment Analysis proved that the expression level of TBX5-AS1 increased following the activation of the androgen signaling pathway. In pan-cancer analysis, the prognostic prediction based on gender grouping obtained more meaningful results, and the synergy between TBX5-AS1 and its homologous target was more consistent. Furthermore, immunity variations between sexes prompted us to explore the role that TBX5-AS1 played in tumor microenvironment and immunotherapy. The robust evidence proved that male patients with high expression of TBX5-AS1 possessed a malignant immune microenvironment and urgently needed immune checkpoint inhibitor treatment. In conclusion, TBX5-AS1 may be one of the strongest candidates to predict prognosis for male patients with SCC and provide a reference for immunotherapy.
format	article
author	Tao Yan Kai Wang Qidi Zhao Junjie Zhuang Hongchang Shen Guoyuan Ma Lei Cong Jiajun Du
author_facet	Tao Yan Kai Wang Qidi Zhao Junjie Zhuang Hongchang Shen Guoyuan Ma Lei Cong Jiajun Du
author_sort	Tao Yan
title	Gender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening
title_short	Gender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening
title_full	Gender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening
title_fullStr	Gender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening
title_full_unstemmed	Gender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening
title_sort	gender specific erna tbx5-as1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening
publisher	PeerJ Inc.
publishDate	2021
url	https://doaj.org/article/f0cdc809e27244219b1c2dca14e88eb2
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Gender specific eRNA TBX5-AS1 as the immunological biomarker for male patients with lung squamous cell carcinoma in pan-cancer screening

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