ENDOTHELIAL DYSFUNCTION AND “OXIDATIVE STRESS” BY THE NONNSTABLE COURSE OF ISCHEMIC HEART DISEASE

Abstract. The purpose of study was to compare phagocytic indexes, free oxygen radicals generation, activity of antioxidative protection, cytokine levels and von Willebrand factor (vWF) antigen in the patients with non–stable course of ischemic heart disease of. We examined 58 patients with ischemic...

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Autores principales:	A. E. Kratnov, A. G. Borodin, A. A. Kratnov, E. S. Uglov, O. V. Shilova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	ischemic heart disease endothelial dysfunction antioxidative protection phagocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f0ce9052422741fd961bc6f85836ace7
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spelling	oai:doaj.org-article:f0ce9052422741fd961bc6f85836ace72021-11-18T08:03:43ZENDOTHELIAL DYSFUNCTION AND “OXIDATIVE STRESS” BY THE NONNSTABLE COURSE OF ISCHEMIC HEART DISEASE1563-06252313-741X10.15789/1563-0625-2005-5-6-569-574https://doaj.org/article/f0ce9052422741fd961bc6f85836ace72014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/627https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The purpose of study was to compare phagocytic indexes, free oxygen radicals generation, activity of antioxidative protection, cytokine levels and von Willebrand factor (vWF) antigen in the patients with non–stable course of ischemic heart disease of. We examined 58 patients with ischemic heart disease: 31 with unstable angina and 27 with acute myocardial infarction. The methods of study included nitro–blue tetrasolium reduction test for neutrophiles and monocytes, detection of myeloperoxidase in phagocytes, assays of glutatione reductase in neutrophiles, as well as measurements of catalase, superoxide dismutase, malonic dialdehyde, circulating immune complexes, IL–6, TNFα and vWF factor antigen in blood. Upon admission to the hospital, the patients with unstable angina, as well as with acute myocardial infarction showed significantly higher levels of vWF, C–reactive protein, neutrophile myeloperoxidase and appropriate trends in circulating immune complexes, IL–6 and TNFα. In the patients admitted to the hospital with ischemic heart disease with repeated coronary events during the last year of follow–up, as well as in acute myocardial infarction, the levels of vWF antigen were found to be significantly increased. The raise of vWF was accompanied by increased levels of malonic dialdehyde, C3R–induced generation of free oxygen radicals in the neutrophils, and drop in glutatione reductase activity, thus reflecting an “oxidative stress” condition. These patients did also exhibit higher levels of C–reactive protein, circulating immune complexes, IL–6 and TNFα. According to regression analysis data, the levels of vWF antigen and C3R–induced activation free oxygen radicals in neutrophils are the indices that were most closely connected to ischemic heart failure disease within a year of observation. The results obtained point to the important role of “oxidative stress” in the development of endothelial dysfunction in the patients with non–stable course of ischemic heart disease. (Med. Immunol., 2005, vol.7, № 5–6, pp. 569–574)A. E. KratnovA. G. BorodinA. A. KratnovE. S. UglovO. V. ShilovaSPb RAACIarticleischemic heart diseaseendothelial dysfunctionantioxidative protectionphagocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 569-574 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	ischemic heart disease endothelial dysfunction antioxidative protection phagocytes Immunologic diseases. Allergy RC581-607
spellingShingle	ischemic heart disease endothelial dysfunction antioxidative protection phagocytes Immunologic diseases. Allergy RC581-607 A. E. Kratnov A. G. Borodin A. A. Kratnov E. S. Uglov O. V. Shilova ENDOTHELIAL DYSFUNCTION AND “OXIDATIVE STRESS” BY THE NONNSTABLE COURSE OF ISCHEMIC HEART DISEASE
description	Abstract. The purpose of study was to compare phagocytic indexes, free oxygen radicals generation, activity of antioxidative protection, cytokine levels and von Willebrand factor (vWF) antigen in the patients with non–stable course of ischemic heart disease of. We examined 58 patients with ischemic heart disease: 31 with unstable angina and 27 with acute myocardial infarction. The methods of study included nitro–blue tetrasolium reduction test for neutrophiles and monocytes, detection of myeloperoxidase in phagocytes, assays of glutatione reductase in neutrophiles, as well as measurements of catalase, superoxide dismutase, malonic dialdehyde, circulating immune complexes, IL–6, TNFα and vWF factor antigen in blood. Upon admission to the hospital, the patients with unstable angina, as well as with acute myocardial infarction showed significantly higher levels of vWF, C–reactive protein, neutrophile myeloperoxidase and appropriate trends in circulating immune complexes, IL–6 and TNFα. In the patients admitted to the hospital with ischemic heart disease with repeated coronary events during the last year of follow–up, as well as in acute myocardial infarction, the levels of vWF antigen were found to be significantly increased. The raise of vWF was accompanied by increased levels of malonic dialdehyde, C3R–induced generation of free oxygen radicals in the neutrophils, and drop in glutatione reductase activity, thus reflecting an “oxidative stress” condition. These patients did also exhibit higher levels of C–reactive protein, circulating immune complexes, IL–6 and TNFα. According to regression analysis data, the levels of vWF antigen and C3R–induced activation free oxygen radicals in neutrophils are the indices that were most closely connected to ischemic heart failure disease within a year of observation. The results obtained point to the important role of “oxidative stress” in the development of endothelial dysfunction in the patients with non–stable course of ischemic heart disease. (Med. Immunol., 2005, vol.7, № 5–6, pp. 569–574)
format	article
author	A. E. Kratnov A. G. Borodin A. A. Kratnov E. S. Uglov O. V. Shilova
author_facet	A. E. Kratnov A. G. Borodin A. A. Kratnov E. S. Uglov O. V. Shilova
author_sort	A. E. Kratnov
title	ENDOTHELIAL DYSFUNCTION AND “OXIDATIVE STRESS” BY THE NONNSTABLE COURSE OF ISCHEMIC HEART DISEASE
title_short	ENDOTHELIAL DYSFUNCTION AND “OXIDATIVE STRESS” BY THE NONNSTABLE COURSE OF ISCHEMIC HEART DISEASE
title_full	ENDOTHELIAL DYSFUNCTION AND “OXIDATIVE STRESS” BY THE NONNSTABLE COURSE OF ISCHEMIC HEART DISEASE
title_fullStr	ENDOTHELIAL DYSFUNCTION AND “OXIDATIVE STRESS” BY THE NONNSTABLE COURSE OF ISCHEMIC HEART DISEASE
title_full_unstemmed	ENDOTHELIAL DYSFUNCTION AND “OXIDATIVE STRESS” BY THE NONNSTABLE COURSE OF ISCHEMIC HEART DISEASE
title_sort	endothelial dysfunction and “oxidative stress” by the nonnstable course of ischemic heart disease
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/f0ce9052422741fd961bc6f85836ace7
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ENDOTHELIAL DYSFUNCTION AND “OXIDATIVE STRESS” BY THE NONNSTABLE COURSE OF ISCHEMIC HEART DISEASE

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