Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease

Abstract Cognitive impairment in Parkinson’s disease (PD) adversely influences quality of life. There is currently no available biomarker to predict cognitive decline in PD. Corneal confocal microscopy (CCM) has been used as a non-invasive tool for quantifying small nerve damage in PD. The present s...

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Autores principales:	Ning-Ning Che, Qiu-Huan Jiang, Guan-Xiao Ding, Si-Yuan Chen, Zhen-Xiang Zhao, Xue Li, Rayaz A. Malik, Jian-Jun Ma, Hong-Qi Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f0cf9edbf35a4feda31db5a970887a13
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spelling	oai:doaj.org-article:f0cf9edbf35a4feda31db5a970887a132021-12-02T17:19:18ZCorneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease10.1038/s41531-021-00225-32373-8057https://doaj.org/article/f0cf9edbf35a4feda31db5a970887a132021-09-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00225-3https://doaj.org/toc/2373-8057Abstract Cognitive impairment in Parkinson’s disease (PD) adversely influences quality of life. There is currently no available biomarker to predict cognitive decline in PD. Corneal confocal microscopy (CCM) has been used as a non-invasive tool for quantifying small nerve damage in PD. The present study investigated whether corneal nerve measures were associated with cognitive function in PD. Patients with PD were classified into those with normal cognitive function (PD-CN), mild cognitive impairment (PD-MCI), and dementia (PDD). Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), and corneal nerve fiber length (CNFL) were quantified with CCM and compared with a control group. Sixty-five PD patients and thirty controls were studied. CNFD was decreased and CNBD was increased in PD patients compared to controls (P < 0.05). CNBD and CNBD/CNFD ratio was higher in PD-CN compared to controls. CNFD was positively correlated with the Montreal cognitive assessment (MoCA) score (r = 0.683, P < 0.001), but negatively associated with unified Parkinson disease rating scale (UPDRS)-part III (r = −0.481, P < 0.001) and total UPDRS scores (r = −0.401, P = 0.001) in PD patients. There was no correlation between CNFD and Levodopa equivalent daily dose (LEDD) (r = 0.176, P = 0.161). CNFD, CNBD, CNFL, and CNBD/CNFD ratio was lower with increasing Hoehn and Yahr stage. PD patients show evidence of corneal nerve loss compared with controls and corneal nerve parameters are associated with the severity of cognitive and motor dysfunction in PD. CCM could serve as an objective in vivo ophthalmic imaging technique to assess neurodegeneration in PD.Ning-Ning CheQiu-Huan JiangGuan-Xiao DingSi-Yuan ChenZhen-Xiang ZhaoXue LiRayaz A. MalikJian-Jun MaHong-Qi YangNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Ning-Ning Che Qiu-Huan Jiang Guan-Xiao Ding Si-Yuan Chen Zhen-Xiang Zhao Xue Li Rayaz A. Malik Jian-Jun Ma Hong-Qi Yang Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease
description	Abstract Cognitive impairment in Parkinson’s disease (PD) adversely influences quality of life. There is currently no available biomarker to predict cognitive decline in PD. Corneal confocal microscopy (CCM) has been used as a non-invasive tool for quantifying small nerve damage in PD. The present study investigated whether corneal nerve measures were associated with cognitive function in PD. Patients with PD were classified into those with normal cognitive function (PD-CN), mild cognitive impairment (PD-MCI), and dementia (PDD). Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), and corneal nerve fiber length (CNFL) were quantified with CCM and compared with a control group. Sixty-five PD patients and thirty controls were studied. CNFD was decreased and CNBD was increased in PD patients compared to controls (P < 0.05). CNBD and CNBD/CNFD ratio was higher in PD-CN compared to controls. CNFD was positively correlated with the Montreal cognitive assessment (MoCA) score (r = 0.683, P < 0.001), but negatively associated with unified Parkinson disease rating scale (UPDRS)-part III (r = −0.481, P < 0.001) and total UPDRS scores (r = −0.401, P = 0.001) in PD patients. There was no correlation between CNFD and Levodopa equivalent daily dose (LEDD) (r = 0.176, P = 0.161). CNFD, CNBD, CNFL, and CNBD/CNFD ratio was lower with increasing Hoehn and Yahr stage. PD patients show evidence of corneal nerve loss compared with controls and corneal nerve parameters are associated with the severity of cognitive and motor dysfunction in PD. CCM could serve as an objective in vivo ophthalmic imaging technique to assess neurodegeneration in PD.
format	article
author	Ning-Ning Che Qiu-Huan Jiang Guan-Xiao Ding Si-Yuan Chen Zhen-Xiang Zhao Xue Li Rayaz A. Malik Jian-Jun Ma Hong-Qi Yang
author_facet	Ning-Ning Che Qiu-Huan Jiang Guan-Xiao Ding Si-Yuan Chen Zhen-Xiang Zhao Xue Li Rayaz A. Malik Jian-Jun Ma Hong-Qi Yang
author_sort	Ning-Ning Che
title	Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease
title_short	Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease
title_full	Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease
title_fullStr	Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease
title_full_unstemmed	Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease
title_sort	corneal nerve fiber loss relates to cognitive impairment in patients with parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f0cf9edbf35a4feda31db5a970887a13
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_version_	1718381059276537856

Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson’s disease

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