Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response

Srikanta Dash,1,2 Srinivas Chava,1 Partha K Chandra,1 Yucel Aydin,2 Luis A Balart,2 Tong Wu1 1Department of Pathology and Laboratory Medicine, 2Department of Gastroenterology and Hepatology, Tulane University School of Medicine, New Orleans, LA, USA Abstract: Autophagy is an intracellular lysosomal...

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Autores principales:	Dash S, Chava S, Chandra PK, Aydin Y, Balart LA, Wu T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	hepatocellular carcinoma macroautophagy microautophagy autophagy inhibitor chloroquine hydroxychloroquine sorafenib Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/f0d2280ef3934939957b0585dde38b5c
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spelling	oai:doaj.org-article:f0d2280ef3934939957b0585dde38b5c2021-12-02T07:44:39ZAutophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response1179-1535https://doaj.org/article/f0d2280ef3934939957b0585dde38b5c2016-02-01T00:00:00Zhttps://www.dovepress.com/autophagy-in-hepatocellular-carcinomas-from-pathophysiology-to-therape-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Srikanta Dash,1,2 Srinivas Chava,1 Partha K Chandra,1 Yucel Aydin,2 Luis A Balart,2 Tong Wu1 1Department of Pathology and Laboratory Medicine, 2Department of Gastroenterology and Hepatology, Tulane University School of Medicine, New Orleans, LA, USA Abstract: Autophagy is an intracellular lysosomal degradation process performed by the cells to maintain energy balance. The autophagy response plays an important role in the progression of liver disease due to hepatitis virus infection, alcoholic liver disease, nonalcoholic fatty liver disease, liver cirrhosis, and hepatocellular carcinoma (HCC). An increased autophagy response also contributes to the pathogenesis of liver disease through modulation of innate and adaptive immune responses; a defective cellular autophagy response leads to the development of HCC. Recent progress in the field indicates that autophagy modulation provides a novel targeted therapy for human liver cancer. The purpose of this review is to update our understanding of how the cellular autophagy response impacts the pathophysiology of liver disease and HCC treatment. Keywords: hepatocellular carcinoma, macroautophagy, microautophagy, autophagy inhibitor, chloroquine, hydroxychloroquine, sorafenibDash SChava SChandra PKAydin YBalart LAWu TDove Medical Pressarticlehepatocellular carcinomamacroautophagymicroautophagyautophagy inhibitorchloroquinehydroxychloroquinesorafenibDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2016, Iss Issue 1, Pp 9-20 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma macroautophagy microautophagy autophagy inhibitor chloroquine hydroxychloroquine sorafenib Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	hepatocellular carcinoma macroautophagy microautophagy autophagy inhibitor chloroquine hydroxychloroquine sorafenib Diseases of the digestive system. Gastroenterology RC799-869 Dash S Chava S Chandra PK Aydin Y Balart LA Wu T Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response
description	Srikanta Dash,1,2 Srinivas Chava,1 Partha K Chandra,1 Yucel Aydin,2 Luis A Balart,2 Tong Wu1 1Department of Pathology and Laboratory Medicine, 2Department of Gastroenterology and Hepatology, Tulane University School of Medicine, New Orleans, LA, USA Abstract: Autophagy is an intracellular lysosomal degradation process performed by the cells to maintain energy balance. The autophagy response plays an important role in the progression of liver disease due to hepatitis virus infection, alcoholic liver disease, nonalcoholic fatty liver disease, liver cirrhosis, and hepatocellular carcinoma (HCC). An increased autophagy response also contributes to the pathogenesis of liver disease through modulation of innate and adaptive immune responses; a defective cellular autophagy response leads to the development of HCC. Recent progress in the field indicates that autophagy modulation provides a novel targeted therapy for human liver cancer. The purpose of this review is to update our understanding of how the cellular autophagy response impacts the pathophysiology of liver disease and HCC treatment. Keywords: hepatocellular carcinoma, macroautophagy, microautophagy, autophagy inhibitor, chloroquine, hydroxychloroquine, sorafenib
format	article
author	Dash S Chava S Chandra PK Aydin Y Balart LA Wu T
author_facet	Dash S Chava S Chandra PK Aydin Y Balart LA Wu T
author_sort	Dash S
title	Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response
title_short	Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response
title_full	Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response
title_fullStr	Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response
title_full_unstemmed	Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response
title_sort	autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/f0d2280ef3934939957b0585dde38b5c
work_keys_str_mv	AT dashs autophagyinhepatocellularcarcinomasfrompathophysiologytotherapeuticresponse AT chavas autophagyinhepatocellularcarcinomasfrompathophysiologytotherapeuticresponse AT chandrapk autophagyinhepatocellularcarcinomasfrompathophysiologytotherapeuticresponse AT aydiny autophagyinhepatocellularcarcinomasfrompathophysiologytotherapeuticresponse AT balartla autophagyinhepatocellularcarcinomasfrompathophysiologytotherapeuticresponse AT wut autophagyinhepatocellularcarcinomasfrompathophysiologytotherapeuticresponse
_version_	1718399255248371712

Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response

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