Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways

Polysaccharides are one of many bioactive compounds found in edible mushrooms. Edible mushrooms have become attractive as “health foods” and as source materials for immunomodulators. The aim of this project was to study the immunoregulatory effects of a purified polysaccharide derived from wild Russ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qian Chen, Chong Qi, Gong Peng, Yang Liu, Xinyuan Zhang, Zhaoli Meng
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	russula griseocarnosa polysaccharide macrophage Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f0d2cbad0f8c427285b2cb72f9f3211e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f0d2cbad0f8c427285b2cb72f9f3211e
record_format	dspace
spelling	oai:doaj.org-article:f0d2cbad0f8c427285b2cb72f9f3211e2021-11-26T11:19:46ZImmune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways0954-01051465-344310.1080/09540105.2018.1461198https://doaj.org/article/f0d2cbad0f8c427285b2cb72f9f3211e2018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1461198https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Polysaccharides are one of many bioactive compounds found in edible mushrooms. Edible mushrooms have become attractive as “health foods” and as source materials for immunomodulators. The aim of this project was to study the immunoregulatory effects of a purified polysaccharide derived from wild Russula griseocarnosa (PRG1-1) on macrophages. Our data showed that in RAW264.7 macrophage cells, PRG1-1 increased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, PRG1-1 increased the production of nitric oxide (NO) and cytokines, including interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-α). Western blotting demonstrated that the regulation of NO and cytokines was mediated through the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways. Therefore, PRG1-1 has the capacity to activate macrophages via the NF-κB and MAPK pathways. These findings helped to elucidate the immune-modulatory properties of the polysaccharide from R. griseocarnosa.Qian ChenChong QiGong PengYang LiuXinyuan ZhangZhaoli MengTaylor & Francis Grouparticlerussula griseocarnosapolysaccharidemacrophageAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 833-844 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	russula griseocarnosa polysaccharide macrophage Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	russula griseocarnosa polysaccharide macrophage Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Qian Chen Chong Qi Gong Peng Yang Liu Xinyuan Zhang Zhaoli Meng Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways
description	Polysaccharides are one of many bioactive compounds found in edible mushrooms. Edible mushrooms have become attractive as “health foods” and as source materials for immunomodulators. The aim of this project was to study the immunoregulatory effects of a purified polysaccharide derived from wild Russula griseocarnosa (PRG1-1) on macrophages. Our data showed that in RAW264.7 macrophage cells, PRG1-1 increased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, PRG1-1 increased the production of nitric oxide (NO) and cytokines, including interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-α). Western blotting demonstrated that the regulation of NO and cytokines was mediated through the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways. Therefore, PRG1-1 has the capacity to activate macrophages via the NF-κB and MAPK pathways. These findings helped to elucidate the immune-modulatory properties of the polysaccharide from R. griseocarnosa.
format	article
author	Qian Chen Chong Qi Gong Peng Yang Liu Xinyuan Zhang Zhaoli Meng
author_facet	Qian Chen Chong Qi Gong Peng Yang Liu Xinyuan Zhang Zhaoli Meng
author_sort	Qian Chen
title	Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways
title_short	Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways
title_full	Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways
title_fullStr	Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways
title_full_unstemmed	Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways
title_sort	immune-enhancing effects of a polysaccharide prg1-1 from russula griseocarnosa on raw264.7 macrophage cells via the mapk and nf-κb signalling pathways
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/f0d2cbad0f8c427285b2cb72f9f3211e
work_keys_str_mv	AT qianchen immuneenhancingeffectsofapolysaccharideprg11fromrussulagriseocarnosaonraw2647macrophagecellsviathemapkandnfkbsignallingpathways AT chongqi immuneenhancingeffectsofapolysaccharideprg11fromrussulagriseocarnosaonraw2647macrophagecellsviathemapkandnfkbsignallingpathways AT gongpeng immuneenhancingeffectsofapolysaccharideprg11fromrussulagriseocarnosaonraw2647macrophagecellsviathemapkandnfkbsignallingpathways AT yangliu immuneenhancingeffectsofapolysaccharideprg11fromrussulagriseocarnosaonraw2647macrophagecellsviathemapkandnfkbsignallingpathways AT xinyuanzhang immuneenhancingeffectsofapolysaccharideprg11fromrussulagriseocarnosaonraw2647macrophagecellsviathemapkandnfkbsignallingpathways AT zhaolimeng immuneenhancingeffectsofapolysaccharideprg11fromrussulagriseocarnosaonraw2647macrophagecellsviathemapkandnfkbsignallingpathways
_version_	1718409570084192256

Immune-enhancing effects of a polysaccharide PRG1-1 from Russula griseocarnosa on RAW264.7 macrophage cells via the MAPK and NF-κB signalling pathways

Ejemplares similares