Towards a common template for neural reinforcement of finger individuation

Abstract The inability to individuate finger movements is a common impairment following stroke. Conventional physical therapy ignores underlying neural changes with recovery, leaving it unclear why sensorimotor function often remains impaired. Functional MRI neurofeedback can monitor neural activity...

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Autores principales:	Justin Kilmarx, Ethan Oblak, James Sulzer, Jarrod Lewis-Peacock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0dae925f1b641979663be14ee45c16f
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id	oai:doaj.org-article:f0dae925f1b641979663be14ee45c16f
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spelling	oai:doaj.org-article:f0dae925f1b641979663be14ee45c16f2021-12-02T15:23:10ZTowards a common template for neural reinforcement of finger individuation10.1038/s41598-020-80166-82045-2322https://doaj.org/article/f0dae925f1b641979663be14ee45c16f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80166-8https://doaj.org/toc/2045-2322Abstract The inability to individuate finger movements is a common impairment following stroke. Conventional physical therapy ignores underlying neural changes with recovery, leaving it unclear why sensorimotor function often remains impaired. Functional MRI neurofeedback can monitor neural activity and reinforce it towards a healthy template to restore function. However, identifying an individualized training template may not be possible depending on the severity of impairment. In this study, we investigated the use of functional alignment of brain data across healthy participants to create an idealized neural template to be used as a training target for new participants. We employed multi-voxel pattern analyses to assess the prediction accuracy and robustness to missing data of pre-trained functional templates corresponding to individual finger presses. We found a significant improvement in classification accuracy (p < 0.001) of individual finger presses when group data was aligned based on function (88%) rather than anatomy (46%). Importantly, we found no significant drop in performance when aligning a new participant to a pre-established template as compared to including this new participant in the creation of a new template. These results indicate that functionally aligned templates could provide an effective surrogate training target for patients following neurological injury.Justin KilmarxEthan OblakJames SulzerJarrod Lewis-PeacockNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Justin Kilmarx Ethan Oblak James Sulzer Jarrod Lewis-Peacock Towards a common template for neural reinforcement of finger individuation
description	Abstract The inability to individuate finger movements is a common impairment following stroke. Conventional physical therapy ignores underlying neural changes with recovery, leaving it unclear why sensorimotor function often remains impaired. Functional MRI neurofeedback can monitor neural activity and reinforce it towards a healthy template to restore function. However, identifying an individualized training template may not be possible depending on the severity of impairment. In this study, we investigated the use of functional alignment of brain data across healthy participants to create an idealized neural template to be used as a training target for new participants. We employed multi-voxel pattern analyses to assess the prediction accuracy and robustness to missing data of pre-trained functional templates corresponding to individual finger presses. We found a significant improvement in classification accuracy (p < 0.001) of individual finger presses when group data was aligned based on function (88%) rather than anatomy (46%). Importantly, we found no significant drop in performance when aligning a new participant to a pre-established template as compared to including this new participant in the creation of a new template. These results indicate that functionally aligned templates could provide an effective surrogate training target for patients following neurological injury.
format	article
author	Justin Kilmarx Ethan Oblak James Sulzer Jarrod Lewis-Peacock
author_facet	Justin Kilmarx Ethan Oblak James Sulzer Jarrod Lewis-Peacock
author_sort	Justin Kilmarx
title	Towards a common template for neural reinforcement of finger individuation
title_short	Towards a common template for neural reinforcement of finger individuation
title_full	Towards a common template for neural reinforcement of finger individuation
title_fullStr	Towards a common template for neural reinforcement of finger individuation
title_full_unstemmed	Towards a common template for neural reinforcement of finger individuation
title_sort	towards a common template for neural reinforcement of finger individuation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f0dae925f1b641979663be14ee45c16f
work_keys_str_mv	AT justinkilmarx towardsacommontemplateforneuralreinforcementoffingerindividuation AT ethanoblak towardsacommontemplateforneuralreinforcementoffingerindividuation AT jamessulzer towardsacommontemplateforneuralreinforcementoffingerindividuation AT jarrodlewispeacock towardsacommontemplateforneuralreinforcementoffingerindividuation
_version_	1718387301307908096

Towards a common template for neural reinforcement of finger individuation

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