Personalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)

The global spread of tuberculosis remains one of actual problems of public health despite of introduction of public health safety programs. Early, rapid and accurate identification of M. tuberculosis and determination of drug susceptibility are essential for treatment and management of this disease....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	P. A. Khromova, V. V. Sinkov, E. D. Savilov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	m. tuberculosis beijing genotype genes of human immune system personalized treatment of tuberculosis Science Q
Acceso en línea:	https://doaj.org/article/f0dbb844bc2644f9b5a2c578bbe7991e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f0dbb844bc2644f9b5a2c578bbe7991e
record_format	dspace
spelling	oai:doaj.org-article:f0dbb844bc2644f9b5a2c578bbe7991e2021-11-23T06:14:42ZPersonalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)2541-94202587-959610.29413/ABS.2019-4.3.17https://doaj.org/article/f0dbb844bc2644f9b5a2c578bbe7991e2019-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2095https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The global spread of tuberculosis remains one of actual problems of public health despite of introduction of public health safety programs. Early, rapid and accurate identification of M. tuberculosis and determination of drug susceptibility are essential for treatment and management of this disease. Delay in delivering results prolongs potentially inappropriate antituberculosis therapy, contributing to emergence of drug resistance, reducing treatment options and increasing treatment duration and associated costs, resulting in increased mortality and morbidity. Faster, more comprehensive diagnostics will enable earlier use of the most appropriate drug regimen, thus improving patient outcomes and reducing overall healthcare costs. The treatment of infection based on the using of massive antimicrobial therapy with analysis of bacterial strains resistance to first line drugs (FLD) isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), ethambutol (EMB) and streptomycin (SM). However, the public health practitioners pay no attention to functional activity of human immune system genes. The interaction of bacterial genomes and immune system genes plays the major role in infection progress. There is growing evidence that, together with human and environmental factors, Mycobacterium tuberculosis complex strain diversity contributes to the variable outcome of infection and disease in human TB. We suppose that the future of diagnosis and treatment of tuberculosis lies in the field of personal medicine with comprehensive analysis of host and pathogen genes.P. A. KhromovaV. V. SinkovE. D. SavilovScientific Сentre for Family Health and Human Reproduction Problemsarticlem. tuberculosisbeijing genotypegenes of human immune systempersonalized treatment of tuberculosisScienceQRUActa Biomedica Scientifica, Vol 4, Iss 3, Pp 127-137 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	m. tuberculosis beijing genotype genes of human immune system personalized treatment of tuberculosis Science Q
spellingShingle	m. tuberculosis beijing genotype genes of human immune system personalized treatment of tuberculosis Science Q P. A. Khromova V. V. Sinkov E. D. Savilov Personalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)
description	The global spread of tuberculosis remains one of actual problems of public health despite of introduction of public health safety programs. Early, rapid and accurate identification of M. tuberculosis and determination of drug susceptibility are essential for treatment and management of this disease. Delay in delivering results prolongs potentially inappropriate antituberculosis therapy, contributing to emergence of drug resistance, reducing treatment options and increasing treatment duration and associated costs, resulting in increased mortality and morbidity. Faster, more comprehensive diagnostics will enable earlier use of the most appropriate drug regimen, thus improving patient outcomes and reducing overall healthcare costs. The treatment of infection based on the using of massive antimicrobial therapy with analysis of bacterial strains resistance to first line drugs (FLD) isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), ethambutol (EMB) and streptomycin (SM). However, the public health practitioners pay no attention to functional activity of human immune system genes. The interaction of bacterial genomes and immune system genes plays the major role in infection progress. There is growing evidence that, together with human and environmental factors, Mycobacterium tuberculosis complex strain diversity contributes to the variable outcome of infection and disease in human TB. We suppose that the future of diagnosis and treatment of tuberculosis lies in the field of personal medicine with comprehensive analysis of host and pathogen genes.
format	article
author	P. A. Khromova V. V. Sinkov E. D. Savilov
author_facet	P. A. Khromova V. V. Sinkov E. D. Savilov
author_sort	P. A. Khromova
title	Personalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)
title_short	Personalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)
title_full	Personalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)
title_fullStr	Personalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)
title_full_unstemmed	Personalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)
title_sort	personalized approach as a basis for the future diagnosis of tuberculosis (literature review)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/f0dbb844bc2644f9b5a2c578bbe7991e
work_keys_str_mv	AT pakhromova personalizedapproachasabasisforthefuturediagnosisoftuberculosisliteraturereview AT vvsinkov personalizedapproachasabasisforthefuturediagnosisoftuberculosisliteraturereview AT edsavilov personalizedapproachasabasisforthefuturediagnosisoftuberculosisliteraturereview
_version_	1718416984513708032

Personalized Approach as a Basis for the Future Diagnosis of Tuberculosis (Literature Review)

Ejemplares similares