Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

Improving the safety and efficacy of chemotherapeutics will help to enhance their effects. Here, the authors show that intraperitoneal delivery of nanoparticle conjugates of a potent toxin prolongs tumor inhibition and survival as compared to cisplatin in advanced-stage and platinum-resistant ovaria...

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Autores principales: Ruogu Qi, Yongheng Wang, Peter M. Bruno, Haihua Xiao, Yingjie Yu, Ting Li, Sam Lauffer, Wei Wei, Qixian Chen, Xiang Kang, Haiqin Song, Xi Yang, Xing Huang, Alexandre Detappe, Ursula Matulonis, David Pepin, Michael T. Hemann, Michael J. Birrer, P. Peter Ghoroghchian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f0dc96816c7d46518b2fa0a3a04c8ea7
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spelling oai:doaj.org-article:f0dc96816c7d46518b2fa0a3a04c8ea72021-12-02T14:40:58ZNanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer10.1038/s41467-017-02390-72041-1723https://doaj.org/article/f0dc96816c7d46518b2fa0a3a04c8ea72017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02390-7https://doaj.org/toc/2041-1723Improving the safety and efficacy of chemotherapeutics will help to enhance their effects. Here, the authors show that intraperitoneal delivery of nanoparticle conjugates of a potent toxin prolongs tumor inhibition and survival as compared to cisplatin in advanced-stage and platinum-resistant ovarian cancer mouse models.Ruogu QiYongheng WangPeter M. BrunoHaihua XiaoYingjie YuTing LiSam LaufferWei WeiQixian ChenXiang KangHaiqin SongXi YangXing HuangAlexandre DetappeUrsula MatulonisDavid PepinMichael T. HemannMichael J. BirrerP. Peter GhoroghchianNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ruogu Qi
Yongheng Wang
Peter M. Bruno
Haihua Xiao
Yingjie Yu
Ting Li
Sam Lauffer
Wei Wei
Qixian Chen
Xiang Kang
Haiqin Song
Xi Yang
Xing Huang
Alexandre Detappe
Ursula Matulonis
David Pepin
Michael T. Hemann
Michael J. Birrer
P. Peter Ghoroghchian
Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
description Improving the safety and efficacy of chemotherapeutics will help to enhance their effects. Here, the authors show that intraperitoneal delivery of nanoparticle conjugates of a potent toxin prolongs tumor inhibition and survival as compared to cisplatin in advanced-stage and platinum-resistant ovarian cancer mouse models.
format article
author Ruogu Qi
Yongheng Wang
Peter M. Bruno
Haihua Xiao
Yingjie Yu
Ting Li
Sam Lauffer
Wei Wei
Qixian Chen
Xiang Kang
Haiqin Song
Xi Yang
Xing Huang
Alexandre Detappe
Ursula Matulonis
David Pepin
Michael T. Hemann
Michael J. Birrer
P. Peter Ghoroghchian
author_facet Ruogu Qi
Yongheng Wang
Peter M. Bruno
Haihua Xiao
Yingjie Yu
Ting Li
Sam Lauffer
Wei Wei
Qixian Chen
Xiang Kang
Haiqin Song
Xi Yang
Xing Huang
Alexandre Detappe
Ursula Matulonis
David Pepin
Michael T. Hemann
Michael J. Birrer
P. Peter Ghoroghchian
author_sort Ruogu Qi
title Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
title_short Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
title_full Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
title_fullStr Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
title_full_unstemmed Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
title_sort nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/f0dc96816c7d46518b2fa0a3a04c8ea7
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