Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

Induction of the cis form of phosphorylated tau (cis P-tau) has previously been shown to occur in animal models of traumatic brain injury (TBI), and blocking this form of tau using antibody was beneficial in a rodent model of severe TBI. Here the authors show that cis P-tau induction is a feature of...

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Autores principales:	Onder Albayram, Asami Kondo, Rebekah Mannix, Colin Smith, Cheng-Yu Tsai, Chenyu Li, Megan K. Herbert, Jianhua Qiu, Michael Monuteaux, Jane Driver, Sandra Yan, William Gormley, Ava M. Puccio, David O. Okonkwo, Brandon Lucke-Wold, Julian Bailes, William Meehan, Mark Zeidel, Kun Ping Lu, Xiao Zhen Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0e04206042c42f8b64f0f65a55b5146
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spelling	oai:doaj.org-article:f0e04206042c42f8b64f0f65a55b51462021-12-02T15:38:43ZCis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae10.1038/s41467-017-01068-42041-1723https://doaj.org/article/f0e04206042c42f8b64f0f65a55b51462017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01068-4https://doaj.org/toc/2041-1723Induction of the cis form of phosphorylated tau (cis P-tau) has previously been shown to occur in animal models of traumatic brain injury (TBI), and blocking this form of tau using antibody was beneficial in a rodent model of severe TBI. Here the authors show that cis P-tau induction is a feature of several different forms of TBI in humans, and that administration of cis P-tau targeting antibody to rodents reduces or delays pathological features of TBI.Onder AlbayramAsami KondoRebekah MannixColin SmithCheng-Yu TsaiChenyu LiMegan K. HerbertJianhua QiuMichael MonuteauxJane DriverSandra YanWilliam GormleyAva M. PuccioDavid O. OkonkwoBrandon Lucke-WoldJulian BailesWilliam MeehanMark ZeidelKun Ping LuXiao Zhen ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Onder Albayram Asami Kondo Rebekah Mannix Colin Smith Cheng-Yu Tsai Chenyu Li Megan K. Herbert Jianhua Qiu Michael Monuteaux Jane Driver Sandra Yan William Gormley Ava M. Puccio David O. Okonkwo Brandon Lucke-Wold Julian Bailes William Meehan Mark Zeidel Kun Ping Lu Xiao Zhen Zhou Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
description	Induction of the cis form of phosphorylated tau (cis P-tau) has previously been shown to occur in animal models of traumatic brain injury (TBI), and blocking this form of tau using antibody was beneficial in a rodent model of severe TBI. Here the authors show that cis P-tau induction is a feature of several different forms of TBI in humans, and that administration of cis P-tau targeting antibody to rodents reduces or delays pathological features of TBI.
format	article
author	Onder Albayram Asami Kondo Rebekah Mannix Colin Smith Cheng-Yu Tsai Chenyu Li Megan K. Herbert Jianhua Qiu Michael Monuteaux Jane Driver Sandra Yan William Gormley Ava M. Puccio David O. Okonkwo Brandon Lucke-Wold Julian Bailes William Meehan Mark Zeidel Kun Ping Lu Xiao Zhen Zhou
author_facet	Onder Albayram Asami Kondo Rebekah Mannix Colin Smith Cheng-Yu Tsai Chenyu Li Megan K. Herbert Jianhua Qiu Michael Monuteaux Jane Driver Sandra Yan William Gormley Ava M. Puccio David O. Okonkwo Brandon Lucke-Wold Julian Bailes William Meehan Mark Zeidel Kun Ping Lu Xiao Zhen Zhou
author_sort	Onder Albayram
title	Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
title_short	Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
title_full	Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
title_fullStr	Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
title_full_unstemmed	Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
title_sort	cis p-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f0e04206042c42f8b64f0f65a55b5146
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Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

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