Enlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea

Yanlu Jia, Chunling Liu, Hui Li, Xiaonan Li, Jun Wu, Yimin Zhao, Mengya Xu, Haitao Yu, Zhitong Guan, Shuning Sun, Chao Zhang, Zhiyi Duan Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450000, People’s Republic of ChinaCorrespondence:...

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Autores principales:	Jia Y, Liu C, Li H, Li X, Wu J, Zhao Y, Xu M, Yu H, Guan Z, Sun S, Zhang C, Duan Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obstructive sleep apnea polysomnography sleep mini mental state scale perivascular space Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/f0e0b0e36246459085a31b66b10a1e52
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spelling	oai:doaj.org-article:f0e0b0e36246459085a31b66b10a1e522021-12-02T14:52:07ZEnlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea1179-1608https://doaj.org/article/f0e0b0e36246459085a31b66b10a1e522021-06-01T00:00:00Zhttps://www.dovepress.com/enlarged-perivascular-space-and-its-correlation-with-polysomnography-i-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Yanlu Jia, Chunling Liu, Hui Li, Xiaonan Li, Jun Wu, Yimin Zhao, Mengya Xu, Haitao Yu, Zhitong Guan, Shuning Sun, Chao Zhang, Zhiyi Duan Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450000, People’s Republic of ChinaCorrespondence: Chunling LiuDepartment of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450000, People’s Republic of ChinaEmail liu_cl@126.comPurpose: There is increasing evidence of a causal interaction between obstructive sleep apnea (OSA) and white matter hyperintensity (WMH). WMH and enlarged perivascular space (EPVS) are the neuroimaging markers for cerebral small vessel disease (CSVD). Thus, this study aimed to determine whether a contextual relationship existed between OSA and EPVS.Participants and Methods: In this study, 107 participants underwent 1-night polysomnography, brain magnetic resonance imaging (MRI) and health screening examinations and were classified as 63 OSA patients (mild, moderate, and severe groups), and 44 healthy controls. We assessed the sleep characteristics in OSA group, quantified the total EPVS from MRI and related them to the measures of polysomnography-obtained sleep parameters.Results: Polysomnography revealed that 63 OSA patients had sleep architecture alteration. A higher proportion of N2 phase sleep (N2%), lower percentage of N3 sleep (N3%) and REM sleep (REM%), as well as increased arousal index (AI), oxygen desaturation index (ODI) and decreased lowest arterial oxygen saturation (LSaO2) were detected. The results also indicated a higher prevalence and a larger number of EPVS, and a lower Mini Mental State Scale (MMSE) scale score in OSA group. LSaO2, N3% and REM% were negatively correlated with the total EPVS, whereas ODI, AI and N2% were positively correlated with the total EPVS.Conclusion: The findings suggested that OSA patients had sleep disturbances with a higher incidence and more severe EPVS. Furthermore, the EPVS in OSA might be secondary to sleep disturbances, intermittent hypoxemia and the respiratory event-related hemodynamic changes. Thus, our findings highlighted that increased risk for EPVS in OSA is a potential contributor to increased stroke risk in OSA.Keywords: obstructive sleep apnea, polysomnography, sleep, mini mental state scale, perivascular spaceJia YLiu CLi HLi XWu JZhao YXu MYu HGuan ZSun SZhang CDuan ZDove Medical Pressarticleobstructive sleep apneapolysomnographysleepmini mental state scaleperivascular spacePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 863-872 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obstructive sleep apnea polysomnography sleep mini mental state scale perivascular space Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	obstructive sleep apnea polysomnography sleep mini mental state scale perivascular space Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Jia Y Liu C Li H Li X Wu J Zhao Y Xu M Yu H Guan Z Sun S Zhang C Duan Z Enlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea
description	Yanlu Jia, Chunling Liu, Hui Li, Xiaonan Li, Jun Wu, Yimin Zhao, Mengya Xu, Haitao Yu, Zhitong Guan, Shuning Sun, Chao Zhang, Zhiyi Duan Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450000, People’s Republic of ChinaCorrespondence: Chunling LiuDepartment of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450000, People’s Republic of ChinaEmail liu_cl@126.comPurpose: There is increasing evidence of a causal interaction between obstructive sleep apnea (OSA) and white matter hyperintensity (WMH). WMH and enlarged perivascular space (EPVS) are the neuroimaging markers for cerebral small vessel disease (CSVD). Thus, this study aimed to determine whether a contextual relationship existed between OSA and EPVS.Participants and Methods: In this study, 107 participants underwent 1-night polysomnography, brain magnetic resonance imaging (MRI) and health screening examinations and were classified as 63 OSA patients (mild, moderate, and severe groups), and 44 healthy controls. We assessed the sleep characteristics in OSA group, quantified the total EPVS from MRI and related them to the measures of polysomnography-obtained sleep parameters.Results: Polysomnography revealed that 63 OSA patients had sleep architecture alteration. A higher proportion of N2 phase sleep (N2%), lower percentage of N3 sleep (N3%) and REM sleep (REM%), as well as increased arousal index (AI), oxygen desaturation index (ODI) and decreased lowest arterial oxygen saturation (LSaO2) were detected. The results also indicated a higher prevalence and a larger number of EPVS, and a lower Mini Mental State Scale (MMSE) scale score in OSA group. LSaO2, N3% and REM% were negatively correlated with the total EPVS, whereas ODI, AI and N2% were positively correlated with the total EPVS.Conclusion: The findings suggested that OSA patients had sleep disturbances with a higher incidence and more severe EPVS. Furthermore, the EPVS in OSA might be secondary to sleep disturbances, intermittent hypoxemia and the respiratory event-related hemodynamic changes. Thus, our findings highlighted that increased risk for EPVS in OSA is a potential contributor to increased stroke risk in OSA.Keywords: obstructive sleep apnea, polysomnography, sleep, mini mental state scale, perivascular space
format	article
author	Jia Y Liu C Li H Li X Wu J Zhao Y Xu M Yu H Guan Z Sun S Zhang C Duan Z
author_facet	Jia Y Liu C Li H Li X Wu J Zhao Y Xu M Yu H Guan Z Sun S Zhang C Duan Z
author_sort	Jia Y
title	Enlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea
title_short	Enlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea
title_full	Enlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea
title_fullStr	Enlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea
title_full_unstemmed	Enlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea
title_sort	enlarged perivascular space and its correlation with polysomnography indicators of obstructive sleep apnea
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f0e0b0e36246459085a31b66b10a1e52
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Enlarged Perivascular Space and Its Correlation with Polysomnography Indicators of Obstructive Sleep Apnea

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