Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea

Abstract Eritrea is an East African multiethnic country with an intermediate endemicity for hepatitis B. Our aim was to establish the most prevalent genotypes of hepatitis B virus (HBV) among patients with liver disease. A total of 293 Eritrean patients with liver disease who were hepatitis B surfac...

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Autores principales:	Mohammed Elfatih Hamida, Saud Mohammed Raja, Yodahi Petros, Munir Wahab, Yemane Seyoum, Isam Mohammed Elkhidir, Freweini Tekle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0e15a3df3ec4269833fbf6db6030b56
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spelling	oai:doaj.org-article:f0e15a3df3ec4269833fbf6db6030b562021-12-02T17:50:57ZPrevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea10.1038/s41598-021-90836-w2045-2322https://doaj.org/article/f0e15a3df3ec4269833fbf6db6030b562021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90836-whttps://doaj.org/toc/2045-2322Abstract Eritrea is an East African multiethnic country with an intermediate endemicity for hepatitis B. Our aim was to establish the most prevalent genotypes of hepatitis B virus (HBV) among patients with liver disease. A total of 293 Eritrean patients with liver disease who were hepatitis B surface antigen (HBsAg) positive were enrolled. All sera were tested for liver transaminases, HBV DNA viral load, and hepatitis B seromarkers including HBsAg, anti-HBcAb (total), HBeAg, and anti-HBeAb. Those reactive for HBsAg and anti-HBc (total) were further tested for HBV genotyping. The median (interquartile range) of HBV DNA viral load and ALT levels were 3.47 (1.66) log IU/mL and 28 (15.3) IU/L, respectively. Using type-specific primer-based genotyping method, 122/293 (41.6%) could be genotyped. Irrespective of mode of occurrence, HBV genotype D (21.3%) was the predominant circulating genotype, followed by genotypes C (17.2%), E (15.6%), C/D (13.1%), and C/E (10.7%). Genotypes C/D/E (7.4%), A/D (4.9%), D/E (4.1%), A (2.5%), and B, A/E, B/E, and A/D/C (0.8%) were also present. HBV in Eritrea is comprised of a mixture of HBV genotypes. This is the first study of HBV genotyping among patients with liver disease in Eritrea.Mohammed Elfatih HamidaSaud Mohammed RajaYodahi PetrosMunir WahabYemane SeyoumIsam Mohammed ElkhidirFreweini TekleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammed Elfatih Hamida Saud Mohammed Raja Yodahi Petros Munir Wahab Yemane Seyoum Isam Mohammed Elkhidir Freweini Tekle Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea
description	Abstract Eritrea is an East African multiethnic country with an intermediate endemicity for hepatitis B. Our aim was to establish the most prevalent genotypes of hepatitis B virus (HBV) among patients with liver disease. A total of 293 Eritrean patients with liver disease who were hepatitis B surface antigen (HBsAg) positive were enrolled. All sera were tested for liver transaminases, HBV DNA viral load, and hepatitis B seromarkers including HBsAg, anti-HBcAb (total), HBeAg, and anti-HBeAb. Those reactive for HBsAg and anti-HBc (total) were further tested for HBV genotyping. The median (interquartile range) of HBV DNA viral load and ALT levels were 3.47 (1.66) log IU/mL and 28 (15.3) IU/L, respectively. Using type-specific primer-based genotyping method, 122/293 (41.6%) could be genotyped. Irrespective of mode of occurrence, HBV genotype D (21.3%) was the predominant circulating genotype, followed by genotypes C (17.2%), E (15.6%), C/D (13.1%), and C/E (10.7%). Genotypes C/D/E (7.4%), A/D (4.9%), D/E (4.1%), A (2.5%), and B, A/E, B/E, and A/D/C (0.8%) were also present. HBV in Eritrea is comprised of a mixture of HBV genotypes. This is the first study of HBV genotyping among patients with liver disease in Eritrea.
format	article
author	Mohammed Elfatih Hamida Saud Mohammed Raja Yodahi Petros Munir Wahab Yemane Seyoum Isam Mohammed Elkhidir Freweini Tekle
author_facet	Mohammed Elfatih Hamida Saud Mohammed Raja Yodahi Petros Munir Wahab Yemane Seyoum Isam Mohammed Elkhidir Freweini Tekle
author_sort	Mohammed Elfatih Hamida
title	Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea
title_short	Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea
title_full	Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea
title_fullStr	Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea
title_full_unstemmed	Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea
title_sort	prevalence of hepatitis b virus genotypes among patients with liver disease in eritrea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f0e15a3df3ec4269833fbf6db6030b56
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Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea

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