Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration

The role of the Klf5 in early and postnatal prostate development and in regeneration is unclear. Here, the authors show that Klf5 acetylation regulates and maintains luminal differentiation of prostate basal progenitors and is essential following androgen-induced regeneration.

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Autores principales:	Baotong Zhang, Xinpei Ci, Ran Tao, Jianping Jenny Ni, Xiaoyan Xuan, Jamie L. King, Siyuan Xia, Yixiang Li, Henry F. Frierson, Dong-Kee Lee, Jianming Xu, Adeboye O. Osunkoya, Jin-Tang Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0e28e9d788c4ece9cb9e8d8bdcafded
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spelling	oai:doaj.org-article:f0e28e9d788c4ece9cb9e8d8bdcafded2021-12-02T16:56:49ZKlf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration10.1038/s41467-020-14737-82041-1723https://doaj.org/article/f0e28e9d788c4ece9cb9e8d8bdcafded2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14737-8https://doaj.org/toc/2041-1723The role of the Klf5 in early and postnatal prostate development and in regeneration is unclear. Here, the authors show that Klf5 acetylation regulates and maintains luminal differentiation of prostate basal progenitors and is essential following androgen-induced regeneration.Baotong ZhangXinpei CiRan TaoJianping Jenny NiXiaoyan XuanJamie L. KingSiyuan XiaYixiang LiHenry F. FriersonDong-Kee LeeJianming XuAdeboye O. OsunkoyaJin-Tang DongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baotong Zhang Xinpei Ci Ran Tao Jianping Jenny Ni Xiaoyan Xuan Jamie L. King Siyuan Xia Yixiang Li Henry F. Frierson Dong-Kee Lee Jianming Xu Adeboye O. Osunkoya Jin-Tang Dong Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration
description	The role of the Klf5 in early and postnatal prostate development and in regeneration is unclear. Here, the authors show that Klf5 acetylation regulates and maintains luminal differentiation of prostate basal progenitors and is essential following androgen-induced regeneration.
format	article
author	Baotong Zhang Xinpei Ci Ran Tao Jianping Jenny Ni Xiaoyan Xuan Jamie L. King Siyuan Xia Yixiang Li Henry F. Frierson Dong-Kee Lee Jianming Xu Adeboye O. Osunkoya Jin-Tang Dong
author_facet	Baotong Zhang Xinpei Ci Ran Tao Jianping Jenny Ni Xiaoyan Xuan Jamie L. King Siyuan Xia Yixiang Li Henry F. Frierson Dong-Kee Lee Jianming Xu Adeboye O. Osunkoya Jin-Tang Dong
author_sort	Baotong Zhang
title	Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration
title_short	Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration
title_full	Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration
title_fullStr	Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration
title_full_unstemmed	Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration
title_sort	klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f0e28e9d788c4ece9cb9e8d8bdcafded
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Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration

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