Klf5 acetylation regulates luminal differentiation of basal progenitors in prostate development and regeneration
The role of the Klf5 in early and postnatal prostate development and in regeneration is unclear. Here, the authors show that Klf5 acetylation regulates and maintains luminal differentiation of prostate basal progenitors and is essential following androgen-induced regeneration.
Enregistré dans:
Auteurs principaux: | Baotong Zhang, Xinpei Ci, Ran Tao, Jianping Jenny Ni, Xiaoyan Xuan, Jamie L. King, Siyuan Xia, Yixiang Li, Henry F. Frierson, Dong-Kee Lee, Jianming Xu, Adeboye O. Osunkoya, Jin-Tang Dong |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/f0e28e9d788c4ece9cb9e8d8bdcafded |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
par: Baotong Zhang, et autres
Publié: (2021) -
WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation
par: Mingang Xu, et autres
Publié: (2017) -
Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation
par: Young A. Yoo, et autres
Publié: (2016) -
HIV induces airway basal progenitor cells to adopt an inflammatory phenotype
par: Nancy P. Y. Chung, et autres
Publié: (2021) -
Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
par: Anna D Staniszewska, et autres
Publié: (2012)