Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation

Stavsky et al. examined the effects of deleting the mitochondrial sodium/lithium/calcium exchanger, NCLX, on mitochondrial and synaptic calcium homeostasis, synaptic activity, and plasticity in mice. Having identified a human mutation that impairs NCLX activity and is associated with mental retardat...

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Autores principales:	Alexandra Stavsky, Ohad Stoler, Marko Kostic, Tomer Katoshevsky, Essam A. Assali, Ivana Savic, Yael Amitai, Holger Prokisch, Steffen Leiz, Cornelia Daumer-Haas, Ilya Fleidervish, Fabiana Perrochi, Daniel Gitler, Israel Sekler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f0e2c7e570da4222b9804930f469cda4
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spelling	oai:doaj.org-article:f0e2c7e570da4222b9804930f469cda42021-12-02T15:02:48ZAberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation10.1038/s42003-021-02114-02399-3642https://doaj.org/article/f0e2c7e570da4222b9804930f469cda42021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02114-0https://doaj.org/toc/2399-3642Stavsky et al. examined the effects of deleting the mitochondrial sodium/lithium/calcium exchanger, NCLX, on mitochondrial and synaptic calcium homeostasis, synaptic activity, and plasticity in mice. Having identified a human mutation that impairs NCLX activity and is associated with mental retardation, they show that NCLX is crucial for defining synaptic strength and plasticity, which are pivotal elements of learning and memory.Alexandra StavskyOhad StolerMarko KosticTomer KatoshevskyEssam A. AssaliIvana SavicYael AmitaiHolger ProkischSteffen LeizCornelia Daumer-HaasIlya FleidervishFabiana PerrochiDaniel GitlerIsrael SeklerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Alexandra Stavsky Ohad Stoler Marko Kostic Tomer Katoshevsky Essam A. Assali Ivana Savic Yael Amitai Holger Prokisch Steffen Leiz Cornelia Daumer-Haas Ilya Fleidervish Fabiana Perrochi Daniel Gitler Israel Sekler Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
description	Stavsky et al. examined the effects of deleting the mitochondrial sodium/lithium/calcium exchanger, NCLX, on mitochondrial and synaptic calcium homeostasis, synaptic activity, and plasticity in mice. Having identified a human mutation that impairs NCLX activity and is associated with mental retardation, they show that NCLX is crucial for defining synaptic strength and plasticity, which are pivotal elements of learning and memory.
format	article
author	Alexandra Stavsky Ohad Stoler Marko Kostic Tomer Katoshevsky Essam A. Assali Ivana Savic Yael Amitai Holger Prokisch Steffen Leiz Cornelia Daumer-Haas Ilya Fleidervish Fabiana Perrochi Daniel Gitler Israel Sekler
author_facet	Alexandra Stavsky Ohad Stoler Marko Kostic Tomer Katoshevsky Essam A. Assali Ivana Savic Yael Amitai Holger Prokisch Steffen Leiz Cornelia Daumer-Haas Ilya Fleidervish Fabiana Perrochi Daniel Gitler Israel Sekler
author_sort	Alexandra Stavsky
title	Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
title_short	Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
title_full	Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
title_fullStr	Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
title_full_unstemmed	Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation
title_sort	aberrant activity of mitochondrial nclx is linked to impaired synaptic transmission and is associated with mental retardation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f0e2c7e570da4222b9804930f469cda4
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Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation

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