Cohesin depleted cells rebuild functional nuclear compartments after endomitosis

The role of cohesin in organizing a functional nuclear architecture remains poorly understood. Here the authors show that cohesin depleted cells pass through endomitosis forming a multilobulated nucleus able to proceed through S-phase with typical features of active and inactive nuclear compartments...

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Autores principales:	Marion Cremer, Katharina Brandstetter, Andreas Maiser, Suhas S. P. Rao, Volker J. Schmid, Miguel Guirao-Ortiz, Namita Mitra, Stefania Mamberti, Kyle N. Klein, David M. Gilbert, Heinrich Leonhardt, M. Cristina Cardoso, Erez Lieberman Aiden, Hartmann Harz, Thomas Cremer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0e404681d714c6f838a9676235998d2
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spelling	oai:doaj.org-article:f0e404681d714c6f838a9676235998d22021-12-02T16:50:01ZCohesin depleted cells rebuild functional nuclear compartments after endomitosis10.1038/s41467-020-19876-62041-1723https://doaj.org/article/f0e404681d714c6f838a9676235998d22020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19876-6https://doaj.org/toc/2041-1723The role of cohesin in organizing a functional nuclear architecture remains poorly understood. Here the authors show that cohesin depleted cells pass through endomitosis forming a multilobulated nucleus able to proceed through S-phase with typical features of active and inactive nuclear compartments and spatio-temporal patterns of replication domains.Marion CremerKatharina BrandstetterAndreas MaiserSuhas S. P. RaoVolker J. SchmidMiguel Guirao-OrtizNamita MitraStefania MambertiKyle N. KleinDavid M. GilbertHeinrich LeonhardtM. Cristina CardosoErez Lieberman AidenHartmann HarzThomas CremerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marion Cremer Katharina Brandstetter Andreas Maiser Suhas S. P. Rao Volker J. Schmid Miguel Guirao-Ortiz Namita Mitra Stefania Mamberti Kyle N. Klein David M. Gilbert Heinrich Leonhardt M. Cristina Cardoso Erez Lieberman Aiden Hartmann Harz Thomas Cremer Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
description	The role of cohesin in organizing a functional nuclear architecture remains poorly understood. Here the authors show that cohesin depleted cells pass through endomitosis forming a multilobulated nucleus able to proceed through S-phase with typical features of active and inactive nuclear compartments and spatio-temporal patterns of replication domains.
format	article
author	Marion Cremer Katharina Brandstetter Andreas Maiser Suhas S. P. Rao Volker J. Schmid Miguel Guirao-Ortiz Namita Mitra Stefania Mamberti Kyle N. Klein David M. Gilbert Heinrich Leonhardt M. Cristina Cardoso Erez Lieberman Aiden Hartmann Harz Thomas Cremer
author_facet	Marion Cremer Katharina Brandstetter Andreas Maiser Suhas S. P. Rao Volker J. Schmid Miguel Guirao-Ortiz Namita Mitra Stefania Mamberti Kyle N. Klein David M. Gilbert Heinrich Leonhardt M. Cristina Cardoso Erez Lieberman Aiden Hartmann Harz Thomas Cremer
author_sort	Marion Cremer
title	Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
title_short	Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
title_full	Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
title_fullStr	Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
title_full_unstemmed	Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
title_sort	cohesin depleted cells rebuild functional nuclear compartments after endomitosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f0e404681d714c6f838a9676235998d2
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Cohesin depleted cells rebuild functional nuclear compartments after endomitosis

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