Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice

Autoreactive T cells are normally eliminated during their maturation in the thymus, but an unknown number of autoreactive CD4+ T cells escape to the periphery. Here the authors show, by comparing the T cell receptors of mice sufficient or deficient in CD4+Foxp3+ regulatory T (Treg) cells, that autor...

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Autores principales:	Anna Cebula, Michal Kuczma, Edyta Szurek, Maciej Pietrzak, Natasha Savage, Wessam R. Elhefnawy, Grzegorz Rempala, Piotr Kraj, Leszek Ignatowicz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0ecadad87d6496c8f838eae6f2b9404
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spelling	oai:doaj.org-article:f0ecadad87d6496c8f838eae6f2b94042021-12-02T17:01:40ZDormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice10.1038/s41467-019-12820-32041-1723https://doaj.org/article/f0ecadad87d6496c8f838eae6f2b94042019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12820-3https://doaj.org/toc/2041-1723Autoreactive T cells are normally eliminated during their maturation in the thymus, but an unknown number of autoreactive CD4+ T cells escape to the periphery. Here the authors show, by comparing the T cell receptors of mice sufficient or deficient in CD4+Foxp3+ regulatory T (Treg) cells, that autoreactive and potentially pathogenic clones account for approximately one-third of the peripheral repertoire of CD4+Foxp3– cells.Anna CebulaMichal KuczmaEdyta SzurekMaciej PietrzakNatasha SavageWessam R. ElhefnawyGrzegorz RempalaPiotr KrajLeszek IgnatowiczNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anna Cebula Michal Kuczma Edyta Szurek Maciej Pietrzak Natasha Savage Wessam R. Elhefnawy Grzegorz Rempala Piotr Kraj Leszek Ignatowicz Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice
description	Autoreactive T cells are normally eliminated during their maturation in the thymus, but an unknown number of autoreactive CD4+ T cells escape to the periphery. Here the authors show, by comparing the T cell receptors of mice sufficient or deficient in CD4+Foxp3+ regulatory T (Treg) cells, that autoreactive and potentially pathogenic clones account for approximately one-third of the peripheral repertoire of CD4+Foxp3– cells.
format	article
author	Anna Cebula Michal Kuczma Edyta Szurek Maciej Pietrzak Natasha Savage Wessam R. Elhefnawy Grzegorz Rempala Piotr Kraj Leszek Ignatowicz
author_facet	Anna Cebula Michal Kuczma Edyta Szurek Maciej Pietrzak Natasha Savage Wessam R. Elhefnawy Grzegorz Rempala Piotr Kraj Leszek Ignatowicz
author_sort	Anna Cebula
title	Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice
title_short	Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice
title_full	Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice
title_fullStr	Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice
title_full_unstemmed	Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice
title_sort	dormant pathogenic cd4+ t cells are prevalent in the peripheral repertoire of healthy mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f0ecadad87d6496c8f838eae6f2b9404
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Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice

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