Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice

Autoreactive T cells are normally eliminated during their maturation in the thymus, but an unknown number of autoreactive CD4+ T cells escape to the periphery. Here the authors show, by comparing the T cell receptors of mice sufficient or deficient in CD4+Foxp3+ regulatory T (Treg) cells, that autor...

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Autores principales: Anna Cebula, Michal Kuczma, Edyta Szurek, Maciej Pietrzak, Natasha Savage, Wessam R. Elhefnawy, Grzegorz Rempala, Piotr Kraj, Leszek Ignatowicz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f0ecadad87d6496c8f838eae6f2b9404
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