Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.

<h4>Background</h4>For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population.<h4>Aims</h4>To establish the normal ranges of liver sti...

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Autores principales:	James Fung, Cheuk-kwong Lee, Monica Chan, Wai-kay Seto, Danny Ka-ho Wong, Ching-lung Lai, Man-fung Yuen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0ee6fc5897348daa96e602beb3ef5b8
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spelling	oai:doaj.org-article:f0ee6fc5897348daa96e602beb3ef5b82021-11-18T08:40:14ZDefining normal liver stiffness range in a normal healthy Chinese population without liver disease.1932-620310.1371/journal.pone.0085067https://doaj.org/article/f0ee6fc5897348daa96e602beb3ef5b82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386446/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population.<h4>Aims</h4>To establish the normal ranges of liver stiffness in the healthy Chinese population without underlying liver disease.<h4>Methods</h4>This is a prospective cross sectional study of 2,528 healthy volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All participants underwent a comprehensive questionnaire survey, measurement of weight, height, and blood pressure. Fasting liver function tests, glucose and cholesterol was performed. Abdominal ultrasound and transient elastography were performed on all participants.<h4>Results</h4>Of the 2,528 subjects, 1,998 were excluded with either abnormal liver parenchyma on ultrasound, chronic medical condition, abnormal blood tests including liver enzymes, fasting glucose, fasting cholesterol, high body mass index, high blood pressure, or invalid liver stiffness scan. The reference range for the 530 subjects without known liver disease was 2.3 to 5.9 kPa (mean 4.1, SD 0.89). The median liver stiffness was higher in males compared with females (4.3 vs 4.0 kPa respectively, p<0.001). There was also a decline in median Lliver stiffness in the older age group, from 4.2 kPa in those <25 years to 3.4 kPa for those >55 years (p=0.001).<h4>Conclusions</h4>The healthy reference range for liver stiffness in the Chinese population is 2.3 to 5.9 kPa. Female gender and older age group was associated with a lower median liver stiffness.James FungCheuk-kwong LeeMonica ChanWai-kay SetoDanny Ka-ho WongChing-lung LaiMan-fung YuenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e85067 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q James Fung Cheuk-kwong Lee Monica Chan Wai-kay Seto Danny Ka-ho Wong Ching-lung Lai Man-fung Yuen Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.
description	<h4>Background</h4>For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population.<h4>Aims</h4>To establish the normal ranges of liver stiffness in the healthy Chinese population without underlying liver disease.<h4>Methods</h4>This is a prospective cross sectional study of 2,528 healthy volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All participants underwent a comprehensive questionnaire survey, measurement of weight, height, and blood pressure. Fasting liver function tests, glucose and cholesterol was performed. Abdominal ultrasound and transient elastography were performed on all participants.<h4>Results</h4>Of the 2,528 subjects, 1,998 were excluded with either abnormal liver parenchyma on ultrasound, chronic medical condition, abnormal blood tests including liver enzymes, fasting glucose, fasting cholesterol, high body mass index, high blood pressure, or invalid liver stiffness scan. The reference range for the 530 subjects without known liver disease was 2.3 to 5.9 kPa (mean 4.1, SD 0.89). The median liver stiffness was higher in males compared with females (4.3 vs 4.0 kPa respectively, p<0.001). There was also a decline in median Lliver stiffness in the older age group, from 4.2 kPa in those <25 years to 3.4 kPa for those >55 years (p=0.001).<h4>Conclusions</h4>The healthy reference range for liver stiffness in the Chinese population is 2.3 to 5.9 kPa. Female gender and older age group was associated with a lower median liver stiffness.
format	article
author	James Fung Cheuk-kwong Lee Monica Chan Wai-kay Seto Danny Ka-ho Wong Ching-lung Lai Man-fung Yuen
author_facet	James Fung Cheuk-kwong Lee Monica Chan Wai-kay Seto Danny Ka-ho Wong Ching-lung Lai Man-fung Yuen
author_sort	James Fung
title	Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.
title_short	Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.
title_full	Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.
title_fullStr	Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.
title_full_unstemmed	Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.
title_sort	defining normal liver stiffness range in a normal healthy chinese population without liver disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f0ee6fc5897348daa96e602beb3ef5b8
work_keys_str_mv	AT jamesfung definingnormalliverstiffnessrangeinanormalhealthychinesepopulationwithoutliverdisease AT cheukkwonglee definingnormalliverstiffnessrangeinanormalhealthychinesepopulationwithoutliverdisease AT monicachan definingnormalliverstiffnessrangeinanormalhealthychinesepopulationwithoutliverdisease AT waikayseto definingnormalliverstiffnessrangeinanormalhealthychinesepopulationwithoutliverdisease AT dannykahowong definingnormalliverstiffnessrangeinanormalhealthychinesepopulationwithoutliverdisease AT chinglunglai definingnormalliverstiffnessrangeinanormalhealthychinesepopulationwithoutliverdisease AT manfungyuen definingnormalliverstiffnessrangeinanormalhealthychinesepopulationwithoutliverdisease
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Defining normal liver stiffness range in a normal healthy Chinese population without liver disease.

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