LEVELS OF INTERLEUKINS AND MELATONIN IN PATIENTS WITH ACUTE CORONARY SYNDROME

The issues of cytokine activation in patients with ischemic heart disease (IHD) are widely discussed in medical literature, including both chronic and acute clinical course of the disorder. However, appropriate changes still remain unclear. E.g., attention in research is drawn to possible role of me...

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Autores principales:	M. A. Shalenkova, Z. D. Mikhailova, E. T. Manukova, T. A. Basalgina, A. P. Shishkina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	interleukins 6-hydroxymelatonin myocardial infarction instable angina pectoris stable angina pectoris Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f0eea702a8b74fed81131bd9219ab107
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spelling	oai:doaj.org-article:f0eea702a8b74fed81131bd9219ab1072021-11-18T08:03:44ZLEVELS OF INTERLEUKINS AND MELATONIN IN PATIENTS WITH ACUTE CORONARY SYNDROME1563-06252313-741X10.15789/1563-0625-2014-5-473-480https://doaj.org/article/f0eea702a8b74fed81131bd9219ab1072014-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/735https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe issues of cytokine activation in patients with ischemic heart disease (IHD) are widely discussed in medical literature, including both chronic and acute clinical course of the disorder. However, appropriate changes still remain unclear. E.g., attention in research is drawn to possible role of melatonin (MT), an epiphysis hormone. The available findings on MT production in acute forms of IHD are controversial. We have determined blood levels of IL-6 and IL-10 in 98 patients with IHD, of them 93 suffering from acute coronary syndrome (ACS), and 5, with stable angina pectoris (SAP), functional class II-III, and evaluated their correlation with urinary contents of the MT metabolite (6–hydroxymelatonin, 6-HOMT). ACS patients, when compared with SAP patients, showed an increase of IL-6 and IL-10 levels, whereas 6-HOMT contents were found to be decreased. In the patients with unstable angina pectoris and non-Q myocardial infarction (IM), we have revealed more elevated values of IL-6 and IL-10, as well as 6-HOMT. IL-6 and IL-10 levels appeared to be higher and those of 6-HOMT proved to be lower in patients with a history of anterior IM. The levels of 6-HOMT were found to be significantly increased in the patients with complicated IM. The levels of IL-6 and IL-10 in blood and 6-HOMT in urine can be used as auxiliary diagnostic criteria, in order to predict possible development of cardiovascular complications during ACS during hospital period.M. A. ShalenkovaZ. D. MikhailovaE. T. ManukovaT. A. BasalginaA. P. ShishkinaSPb RAACIarticleinterleukins6-hydroxymelatoninmyocardial infarctioninstable angina pectorisstable angina pectorisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 5, Pp 473-480 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	interleukins 6-hydroxymelatonin myocardial infarction instable angina pectoris stable angina pectoris Immunologic diseases. Allergy RC581-607
spellingShingle	interleukins 6-hydroxymelatonin myocardial infarction instable angina pectoris stable angina pectoris Immunologic diseases. Allergy RC581-607 M. A. Shalenkova Z. D. Mikhailova E. T. Manukova T. A. Basalgina A. P. Shishkina LEVELS OF INTERLEUKINS AND MELATONIN IN PATIENTS WITH ACUTE CORONARY SYNDROME
description	The issues of cytokine activation in patients with ischemic heart disease (IHD) are widely discussed in medical literature, including both chronic and acute clinical course of the disorder. However, appropriate changes still remain unclear. E.g., attention in research is drawn to possible role of melatonin (MT), an epiphysis hormone. The available findings on MT production in acute forms of IHD are controversial. We have determined blood levels of IL-6 and IL-10 in 98 patients with IHD, of them 93 suffering from acute coronary syndrome (ACS), and 5, with stable angina pectoris (SAP), functional class II-III, and evaluated their correlation with urinary contents of the MT metabolite (6–hydroxymelatonin, 6-HOMT). ACS patients, when compared with SAP patients, showed an increase of IL-6 and IL-10 levels, whereas 6-HOMT contents were found to be decreased. In the patients with unstable angina pectoris and non-Q myocardial infarction (IM), we have revealed more elevated values of IL-6 and IL-10, as well as 6-HOMT. IL-6 and IL-10 levels appeared to be higher and those of 6-HOMT proved to be lower in patients with a history of anterior IM. The levels of 6-HOMT were found to be significantly increased in the patients with complicated IM. The levels of IL-6 and IL-10 in blood and 6-HOMT in urine can be used as auxiliary diagnostic criteria, in order to predict possible development of cardiovascular complications during ACS during hospital period.
format	article
author	M. A. Shalenkova Z. D. Mikhailova E. T. Manukova T. A. Basalgina A. P. Shishkina
author_facet	M. A. Shalenkova Z. D. Mikhailova E. T. Manukova T. A. Basalgina A. P. Shishkina
author_sort	M. A. Shalenkova
title	LEVELS OF INTERLEUKINS AND MELATONIN IN PATIENTS WITH ACUTE CORONARY SYNDROME
title_short	LEVELS OF INTERLEUKINS AND MELATONIN IN PATIENTS WITH ACUTE CORONARY SYNDROME
title_full	LEVELS OF INTERLEUKINS AND MELATONIN IN PATIENTS WITH ACUTE CORONARY SYNDROME
title_fullStr	LEVELS OF INTERLEUKINS AND MELATONIN IN PATIENTS WITH ACUTE CORONARY SYNDROME
title_full_unstemmed	LEVELS OF INTERLEUKINS AND MELATONIN IN PATIENTS WITH ACUTE CORONARY SYNDROME
title_sort	levels of interleukins and melatonin in patients with acute coronary syndrome
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/f0eea702a8b74fed81131bd9219ab107
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LEVELS OF INTERLEUKINS AND MELATONIN IN PATIENTS WITH ACUTE CORONARY SYNDROME

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