Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells

Pengfei Zhang,1,* Peicheng Wang,2,* Lei Yan,3 Lifeng Liu1 1Department of Otolaryngology – Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China; 2Department of Otolaryngology – Head and Neck Surgery, W...

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Autores principales:	Zhang P, Wang P, Yan L, Liu L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Solanum xanthocarpum gold nanoparticle nasopharyngeal cancer autophagy apoptosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f0eea7e4047448cf9af5610b4a5dd61f
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spelling	oai:doaj.org-article:f0eea7e4047448cf9af5610b4a5dd61f2021-12-02T06:57:12ZSynthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells1178-2013https://doaj.org/article/f0eea7e4047448cf9af5610b4a5dd61f2018-11-01T00:00:00Zhttps://www.dovepress.com/synthesis-of-gold-nanoparticles-with-solanum-xanthocarpum-extract-and--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Pengfei Zhang,1,* Peicheng Wang,2,* Lei Yan,3 Lifeng Liu1 1Department of Otolaryngology – Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China; 2Department of Otolaryngology – Head and Neck Surgery, Weihai Municipal Hospital, Weihai, Shandong 264200, China; 3Innoscience Research Sdn. Bhd, Subang Jaya, Selangor 47500, Malaysia *These authors contributed equally to this work Background: Nasopharyngeal cancer (NPC) is one of the subtypes of head and neck cancers. It occurs rarely, and its prevalence depends mainly on geographical location. Modern-day research is focused on coupling nanotechnology and traditional medicine for combating cancers. Gold nanoparticles (AuNPs) were synthesized from Solanum xanthocarpum (Sx) leaf extract using reduction method. Methods: Characterization of the synthesized AuNPs was done by different techniques such as ultraviolet–visible spectrum absorption, X-ray diffraction, dynamic light scattering, Fourier transform infrared spectroscopy, transmission electron microscopy, and energy-dispersive X-ray analysis. Results: All the results showed the successful green synthesis of AuNPs from Sx, which induced apoptosis of C666-1 cell line (NPC cell line). There was a decline in both cell viability and colony formation in C666-1 cells upon treatment with Sx-AuNPs. The cell death was proved to be caused by autophagy and mitochondrial-dependent apoptotic pathway. Conclusion: Thus, due to their anticancer potential, these nanoparticles coupled with Sx can be used for in vivo applications and clinical research in future. Keywords: Solanum xanthocarpum, gold nanoparticle, C666-1 cells, ROS, apoptosisZhang PWang PYan LLiu LDove Medical PressarticleSolanum xanthocarpumgold nanoparticlenasopharyngeal cancerautophagyapoptosisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7047-7059 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Solanum xanthocarpum gold nanoparticle nasopharyngeal cancer autophagy apoptosis Medicine (General) R5-920
spellingShingle	Solanum xanthocarpum gold nanoparticle nasopharyngeal cancer autophagy apoptosis Medicine (General) R5-920 Zhang P Wang P Yan L Liu L Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells
description	Pengfei Zhang,1,* Peicheng Wang,2,* Lei Yan,3 Lifeng Liu1 1Department of Otolaryngology – Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China; 2Department of Otolaryngology – Head and Neck Surgery, Weihai Municipal Hospital, Weihai, Shandong 264200, China; 3Innoscience Research Sdn. Bhd, Subang Jaya, Selangor 47500, Malaysia *These authors contributed equally to this work Background: Nasopharyngeal cancer (NPC) is one of the subtypes of head and neck cancers. It occurs rarely, and its prevalence depends mainly on geographical location. Modern-day research is focused on coupling nanotechnology and traditional medicine for combating cancers. Gold nanoparticles (AuNPs) were synthesized from Solanum xanthocarpum (Sx) leaf extract using reduction method. Methods: Characterization of the synthesized AuNPs was done by different techniques such as ultraviolet–visible spectrum absorption, X-ray diffraction, dynamic light scattering, Fourier transform infrared spectroscopy, transmission electron microscopy, and energy-dispersive X-ray analysis. Results: All the results showed the successful green synthesis of AuNPs from Sx, which induced apoptosis of C666-1 cell line (NPC cell line). There was a decline in both cell viability and colony formation in C666-1 cells upon treatment with Sx-AuNPs. The cell death was proved to be caused by autophagy and mitochondrial-dependent apoptotic pathway. Conclusion: Thus, due to their anticancer potential, these nanoparticles coupled with Sx can be used for in vivo applications and clinical research in future. Keywords: Solanum xanthocarpum, gold nanoparticle, C666-1 cells, ROS, apoptosis
format	article
author	Zhang P Wang P Yan L Liu L
author_facet	Zhang P Wang P Yan L Liu L
author_sort	Zhang P
title	Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells
title_short	Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells
title_full	Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells
title_fullStr	Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells
title_full_unstemmed	Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells
title_sort	synthesis of gold nanoparticles with solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f0eea7e4047448cf9af5610b4a5dd61f
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Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells

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