Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.

Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.

Nuclear factor kappa-B (NF-κB) activates multiple genes with overlapping roles in cell proliferation, inflammation and cancer. Using an unbiased approach we identified human CDK6 as a novel kinase phosphorylating NF-κB p65 at serine 536. Purified and reconstituted CDK6/cyclin complexes phosphorylate...

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Autores principales: Holger Buss, Katja Handschick, Nadine Jurrmann, Pirita Pekkonen, Knut Beuerlein, Helmut Müller, Robin Wait, Jeremy Saklatvala, Päivi M Ojala, M Lienhard Schmitz, Michael Naumann, Michael Kracht
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/f0f07af112614169b2d732e1310cee77
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