Turbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging
Purpose: To qualitatively and quantitatively compare the image quality and diagnostic performance of turbo gradient and spin echo PROPELLER diffusion-weighted imaging (TGSE-PROPELLER-DWI) vs. readout-segmented echo-planar imaging (rs-EPI) in the evaluation of orbital tumors.Materials and Methods: A...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:f0f692470b68491e959f056aaf8eabfb2021-12-01T19:30:31ZTurbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging1662-453X10.3389/fnins.2021.755327https://doaj.org/article/f0f692470b68491e959f056aaf8eabfb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.755327/fullhttps://doaj.org/toc/1662-453XPurpose: To qualitatively and quantitatively compare the image quality and diagnostic performance of turbo gradient and spin echo PROPELLER diffusion-weighted imaging (TGSE-PROPELLER-DWI) vs. readout-segmented echo-planar imaging (rs-EPI) in the evaluation of orbital tumors.Materials and Methods: A total of 43 patients with suspected orbital tumors were enrolled to perform the two DWIs with comparable spatial resolution on 3T. The overall image qualities, geometric distortions, susceptibility artifacts, and lesion conspicuities were scored by using a four-point scale (1, poor; 4, excellent). Quantitative measurements, including contrast-to-noise ratios (CNRs), apparent diffusion coefficients (ADCs), geometric distortion rates (GDRs), and lesion sizes, were calculated and compared. The two ADCs for differentiating malignant from benign orbital tumors were evaluated. Wilcoxon signed-rank test, Kappa statistic, and receiver operating characteristics (ROC) curves were used.Results: TGSE-PROPELLER-DWI performed superior in all subjective scores and quantitative GDR evaluation than rs-EPI (p < 0.001), and excellent interobserver agreement was obtained for Kappa value ranging from 0.876 to 1.000. ADClesion of TGSE-PROPELLER-DWI was significantly higher than those of rs-EPI (p < 0.001). Mean ADC of malignant tumors was significantly lower than that of benign tumors both in two DWIs. However, the AUC for differentiating malignant and benign tumors showed no significant difference in the two DWIs (0.860 vs. 0.854, p = 0.7448). Sensitivity and specificity could achieve 92.86% and 72.73% for TGSE-PROPELLER-DWI with a cutoff value of 1.23 × 10–3 mm2/s, and 85.71% and 81.82% for rs-EPI with a cutoff value of 0.99 × 10–3 mm2/s.Conclusion: Compared with rs-EPI, TGSE-PROPELLER-DWI showed minimized geometric distortion and susceptibility artifacts significantly improved the image quality for orbital tumors and achieved comparable diagnostic performance in differentiating malignant and benign orbital tumors.Qing FuQing FuXiang-chuang KongXiang-chuang KongDing-Xi LiuDing-Xi LiuKun ZhouYi-hao GuoZi-Qiao LeiZi-Qiao LeiChuan-sheng ZhengChuan-sheng ZhengFan YangFan YangFrontiers Media S.A.articlediffusion weighted imagingapparent diffusion coefficientorbit tumorturbo gradient and spin echo PROPELLER diffusion-weighted imaging (TGSE-PROPELLER-DWI)readout-segmented echo-planar imaging (rs-EPI)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021) |
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| topic |
diffusion weighted imaging apparent diffusion coefficient orbit tumor turbo gradient and spin echo PROPELLER diffusion-weighted imaging (TGSE-PROPELLER-DWI) readout-segmented echo-planar imaging (rs-EPI) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
| spellingShingle |
diffusion weighted imaging apparent diffusion coefficient orbit tumor turbo gradient and spin echo PROPELLER diffusion-weighted imaging (TGSE-PROPELLER-DWI) readout-segmented echo-planar imaging (rs-EPI) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Qing Fu Qing Fu Xiang-chuang Kong Xiang-chuang Kong Ding-Xi Liu Ding-Xi Liu Kun Zhou Yi-hao Guo Zi-Qiao Lei Zi-Qiao Lei Chuan-sheng Zheng Chuan-sheng Zheng Fan Yang Fan Yang Turbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging |
| description |
Purpose: To qualitatively and quantitatively compare the image quality and diagnostic performance of turbo gradient and spin echo PROPELLER diffusion-weighted imaging (TGSE-PROPELLER-DWI) vs. readout-segmented echo-planar imaging (rs-EPI) in the evaluation of orbital tumors.Materials and Methods: A total of 43 patients with suspected orbital tumors were enrolled to perform the two DWIs with comparable spatial resolution on 3T. The overall image qualities, geometric distortions, susceptibility artifacts, and lesion conspicuities were scored by using a four-point scale (1, poor; 4, excellent). Quantitative measurements, including contrast-to-noise ratios (CNRs), apparent diffusion coefficients (ADCs), geometric distortion rates (GDRs), and lesion sizes, were calculated and compared. The two ADCs for differentiating malignant from benign orbital tumors were evaluated. Wilcoxon signed-rank test, Kappa statistic, and receiver operating characteristics (ROC) curves were used.Results: TGSE-PROPELLER-DWI performed superior in all subjective scores and quantitative GDR evaluation than rs-EPI (p < 0.001), and excellent interobserver agreement was obtained for Kappa value ranging from 0.876 to 1.000. ADClesion of TGSE-PROPELLER-DWI was significantly higher than those of rs-EPI (p < 0.001). Mean ADC of malignant tumors was significantly lower than that of benign tumors both in two DWIs. However, the AUC for differentiating malignant and benign tumors showed no significant difference in the two DWIs (0.860 vs. 0.854, p = 0.7448). Sensitivity and specificity could achieve 92.86% and 72.73% for TGSE-PROPELLER-DWI with a cutoff value of 1.23 × 10–3 mm2/s, and 85.71% and 81.82% for rs-EPI with a cutoff value of 0.99 × 10–3 mm2/s.Conclusion: Compared with rs-EPI, TGSE-PROPELLER-DWI showed minimized geometric distortion and susceptibility artifacts significantly improved the image quality for orbital tumors and achieved comparable diagnostic performance in differentiating malignant and benign orbital tumors. |
| format |
article |
| author |
Qing Fu Qing Fu Xiang-chuang Kong Xiang-chuang Kong Ding-Xi Liu Ding-Xi Liu Kun Zhou Yi-hao Guo Zi-Qiao Lei Zi-Qiao Lei Chuan-sheng Zheng Chuan-sheng Zheng Fan Yang Fan Yang |
| author_facet |
Qing Fu Qing Fu Xiang-chuang Kong Xiang-chuang Kong Ding-Xi Liu Ding-Xi Liu Kun Zhou Yi-hao Guo Zi-Qiao Lei Zi-Qiao Lei Chuan-sheng Zheng Chuan-sheng Zheng Fan Yang Fan Yang |
| author_sort |
Qing Fu |
| title |
Turbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging |
| title_short |
Turbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging |
| title_full |
Turbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging |
| title_fullStr |
Turbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging |
| title_full_unstemmed |
Turbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging |
| title_sort |
turbo gradient and spin echo propeller-diffusion weighted imaging for orbital tumors: a comparative study with readout-segmented echo-planar imaging |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/f0f692470b68491e959f056aaf8eabfb |
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