Interleukin-13 genetic variants, household carpet use and childhood asthma.

Interleukin (IL)-13 genetic polymorphisms have shown adverse effects on respiratory health. However, few studies have explored the interactive effects between IL-13 haplotypes and environmental exposures on childhood asthma. The aims of our study are to evaluate the effects of IL-13 genetic variants...

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Autores principales:	Ching-Hui Tsai, Kuan-Yen Tung, Ming-Wei Su, Bor-Luen Chiang, Fook Tim Chew, Nai-Wei Kuo, Yungling Leo Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0f74e6370c54daf853898555e73852a
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spelling	oai:doaj.org-article:f0f74e6370c54daf853898555e73852a2021-11-18T07:59:37ZInterleukin-13 genetic variants, household carpet use and childhood asthma.1932-620310.1371/journal.pone.0051970https://doaj.org/article/f0f74e6370c54daf853898555e73852a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382814/?tool=EBIhttps://doaj.org/toc/1932-6203Interleukin (IL)-13 genetic polymorphisms have shown adverse effects on respiratory health. However, few studies have explored the interactive effects between IL-13 haplotypes and environmental exposures on childhood asthma. The aims of our study are to evaluate the effects of IL-13 genetic variants on asthma phenotypes, and explore the potential interaction between IL-13 and household environmental exposures among Taiwanese children. We investigated 3,577 children in the Taiwan Children Health Study from 14 Taiwanese communities. Data regarding children's exposure and disease status were obtained from parents using a structured questionnaire. Four SNPs were tagged accounting for 100% of the variations in IL-13. Multiple logistic regression models with false-discovery rate (FDR) adjustments were fitted to estimate the effects of IL-13 variants on asthma phenotypes. SNP rs1800925, SNP rs20541 and SNP rs848 were significantly associated with increased risks on childhood wheeze with FDR of 0.03, 0.04 and 0.04, respectively. Children carrying two copies of h1011 haplotype showed increased susceptibility to wheeze. Compared to those without carpet use and h1011 haplotype, children carrying h1011 haplotype and using carpet at home had significantly synergistic risks of wheeze (OR, 2.5; 95% CI, 1.4-4.4; p for interaction, 0.01) and late-onset asthma (OR, 4.7; 95% CI, 2.0-10.9; p for interaction, 0.02). In conclusions, IL-13 genetic variants showed significant adverse effects on asthma phenotypes among children. The results also suggested that asthma pathogenesis might be mediated by household carpet use.Ching-Hui TsaiKuan-Yen TungMing-Wei SuBor-Luen ChiangFook Tim ChewNai-Wei KuoYungling Leo LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e51970 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ching-Hui Tsai Kuan-Yen Tung Ming-Wei Su Bor-Luen Chiang Fook Tim Chew Nai-Wei Kuo Yungling Leo Lee Interleukin-13 genetic variants, household carpet use and childhood asthma.
description	Interleukin (IL)-13 genetic polymorphisms have shown adverse effects on respiratory health. However, few studies have explored the interactive effects between IL-13 haplotypes and environmental exposures on childhood asthma. The aims of our study are to evaluate the effects of IL-13 genetic variants on asthma phenotypes, and explore the potential interaction between IL-13 and household environmental exposures among Taiwanese children. We investigated 3,577 children in the Taiwan Children Health Study from 14 Taiwanese communities. Data regarding children's exposure and disease status were obtained from parents using a structured questionnaire. Four SNPs were tagged accounting for 100% of the variations in IL-13. Multiple logistic regression models with false-discovery rate (FDR) adjustments were fitted to estimate the effects of IL-13 variants on asthma phenotypes. SNP rs1800925, SNP rs20541 and SNP rs848 were significantly associated with increased risks on childhood wheeze with FDR of 0.03, 0.04 and 0.04, respectively. Children carrying two copies of h1011 haplotype showed increased susceptibility to wheeze. Compared to those without carpet use and h1011 haplotype, children carrying h1011 haplotype and using carpet at home had significantly synergistic risks of wheeze (OR, 2.5; 95% CI, 1.4-4.4; p for interaction, 0.01) and late-onset asthma (OR, 4.7; 95% CI, 2.0-10.9; p for interaction, 0.02). In conclusions, IL-13 genetic variants showed significant adverse effects on asthma phenotypes among children. The results also suggested that asthma pathogenesis might be mediated by household carpet use.
format	article
author	Ching-Hui Tsai Kuan-Yen Tung Ming-Wei Su Bor-Luen Chiang Fook Tim Chew Nai-Wei Kuo Yungling Leo Lee
author_facet	Ching-Hui Tsai Kuan-Yen Tung Ming-Wei Su Bor-Luen Chiang Fook Tim Chew Nai-Wei Kuo Yungling Leo Lee
author_sort	Ching-Hui Tsai
title	Interleukin-13 genetic variants, household carpet use and childhood asthma.
title_short	Interleukin-13 genetic variants, household carpet use and childhood asthma.
title_full	Interleukin-13 genetic variants, household carpet use and childhood asthma.
title_fullStr	Interleukin-13 genetic variants, household carpet use and childhood asthma.
title_full_unstemmed	Interleukin-13 genetic variants, household carpet use and childhood asthma.
title_sort	interleukin-13 genetic variants, household carpet use and childhood asthma.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f0f74e6370c54daf853898555e73852a
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Interleukin-13 genetic variants, household carpet use and childhood asthma.

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