Psoriasis and uveitis: links and risks

Christina Fotiadou, Elizabeth LazaridouSecond Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, GreeceCorrespondence: Christina FotiadouSecond Department of Dermatology-Venereology, Aristotle University Medical School, 1 Chrysochoou Street 1221, Larisa, Greece...

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Autores principales:	Fotiadou C, Lazaridou E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Psoriasis Uveitis Pathogenetic Link Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/f0f79b5f53d64d448cd9053b13322fcc
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spelling	oai:doaj.org-article:f0f79b5f53d64d448cd9053b13322fcc2021-12-02T03:32:06ZPsoriasis and uveitis: links and risks2230-326Xhttps://doaj.org/article/f0f79b5f53d64d448cd9053b13322fcc2019-08-01T00:00:00Zhttps://www.dovepress.com/psoriasis-and-uveitis-links-and-risks-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XChristina Fotiadou, Elizabeth LazaridouSecond Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, GreeceCorrespondence: Christina FotiadouSecond Department of Dermatology-Venereology, Aristotle University Medical School, 1 Chrysochoou Street 1221, Larisa, GreeceTel +30 697 728 0180Email christinafotiadou@yahoo.comAbstract: Uveitis, an inflammatory disorder of the mid-portion of the eye, is considered a relatively rare but very serious ocular complication of psoriasis. Data on the specific characteristics of uveitis in the background of psoriasis are extremely limited. The presence of uveitis in the context of psoriasis has been estimated to occur in 7–20% of the psoriasis cases. This incidence tends to be higher in patients suffering from psoriasis and psoriatic arthritis (PsA) or PSA alone. Psoriatic uveitis is usually bilateral, chronic, and severe. In term of pathogenesis, both psoriasis and uveitis are considered as paradigms of T-helper 1/T-helper 17 (Th1/Th17) inflammatory reactions. Certain cytokines such as tumor necrosis factor-α (TNF- α), Interleukin-17 (IL-17), IL-23, and IL-6 play a significant role in the pathogenesis of both psoriasis and uveitis. As uveitis shares common pathogenetic mechanisms with psoriasis in certain circumstances, both diseases may benefit from the same targeted biologic therapies. Undiagnosed and under-treated cases of psoriatic uveitis may cause significant morbidity and even vision loss. Larger prospective studies are needed in order to further investigate the association between these two entities.Keywords: psoriasis, uveitis, pathogenetic linkFotiadou CLazaridou EDove Medical PressarticlePsoriasis Uveitis Pathogenetic LinkDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol Volume 9, Pp 91-96 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psoriasis Uveitis Pathogenetic Link Dermatology RL1-803
spellingShingle	Psoriasis Uveitis Pathogenetic Link Dermatology RL1-803 Fotiadou C Lazaridou E Psoriasis and uveitis: links and risks
description	Christina Fotiadou, Elizabeth LazaridouSecond Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, GreeceCorrespondence: Christina FotiadouSecond Department of Dermatology-Venereology, Aristotle University Medical School, 1 Chrysochoou Street 1221, Larisa, GreeceTel +30 697 728 0180Email christinafotiadou@yahoo.comAbstract: Uveitis, an inflammatory disorder of the mid-portion of the eye, is considered a relatively rare but very serious ocular complication of psoriasis. Data on the specific characteristics of uveitis in the background of psoriasis are extremely limited. The presence of uveitis in the context of psoriasis has been estimated to occur in 7–20% of the psoriasis cases. This incidence tends to be higher in patients suffering from psoriasis and psoriatic arthritis (PsA) or PSA alone. Psoriatic uveitis is usually bilateral, chronic, and severe. In term of pathogenesis, both psoriasis and uveitis are considered as paradigms of T-helper 1/T-helper 17 (Th1/Th17) inflammatory reactions. Certain cytokines such as tumor necrosis factor-α (TNF- α), Interleukin-17 (IL-17), IL-23, and IL-6 play a significant role in the pathogenesis of both psoriasis and uveitis. As uveitis shares common pathogenetic mechanisms with psoriasis in certain circumstances, both diseases may benefit from the same targeted biologic therapies. Undiagnosed and under-treated cases of psoriatic uveitis may cause significant morbidity and even vision loss. Larger prospective studies are needed in order to further investigate the association between these two entities.Keywords: psoriasis, uveitis, pathogenetic link
format	article
author	Fotiadou C Lazaridou E
author_facet	Fotiadou C Lazaridou E
author_sort	Fotiadou C
title	Psoriasis and uveitis: links and risks
title_short	Psoriasis and uveitis: links and risks
title_full	Psoriasis and uveitis: links and risks
title_fullStr	Psoriasis and uveitis: links and risks
title_full_unstemmed	Psoriasis and uveitis: links and risks
title_sort	psoriasis and uveitis: links and risks
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f0f79b5f53d64d448cd9053b13322fcc
work_keys_str_mv	AT fotiadouc psoriasisanduveitislinksandrisks AT lazaridoue psoriasisanduveitislinksandrisks
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Psoriasis and uveitis: links and risks

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