Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Abstract Huntington’s disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms that drive pathology. Expression of the mutant form...

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Main Authors: Valentina Fodale, Roberta Pintauro, Manuel Daldin, Roberta Altobelli, Maria Carolina Spiezia, Monica Bisbocci, Douglas Macdonald, Alberto Bresciani
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/f0f9716e3bb54bde98e7f84e35b5a6f0
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