Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation

Abstract Maternal exposure to environmental contaminants during pregnancy can profoundly influence the risk of developing cardiovascular disease in adult offspring. Our previous studies have demonstrated impaired cardiovascular health, microvascular reactivity, and cardiac function in fetal and youn...

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Autores principales:	Sara B. Fournier, Vincent Lam, Michael J. Goedken, Laura Fabris, Phoebe A. Stapleton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0fb8d62429c4deaa38b111461f5ee6c
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spelling	oai:doaj.org-article:f0fb8d62429c4deaa38b111461f5ee6c2021-12-02T17:37:41ZDevelopment of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation10.1038/s41598-021-98818-82045-2322https://doaj.org/article/f0fb8d62429c4deaa38b111461f5ee6c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98818-8https://doaj.org/toc/2045-2322Abstract Maternal exposure to environmental contaminants during pregnancy can profoundly influence the risk of developing cardiovascular disease in adult offspring. Our previous studies have demonstrated impaired cardiovascular health, microvascular reactivity, and cardiac function in fetal and young adult progeny after maternal inhalation of nano-sized titanium dioxide (nano-TiO2) aerosols during gestation. The present study was designed to evaluate the development of cardiovascular and metabolic diseases later in adulthood. Pregnant Sprague–Dawley rats were exposed to nano-TiO2 aerosols (~ 10 mg/m3, 134 nm median diameter) for 4 h per day, 5 days per week, beginning on gestational day (GD) 4 and ending on GD 19. Progeny were delivered in-house. Body weight was recorded weekly after birth. After 47 weeks, the body weight of exposed progeny was 9.4% greater compared with controls. Heart weight, mean arterial pressure, and plasma biomarkers of inflammation, dyslipidemia, and glycemic control were recorded at 3, 9 and 12 months of age, with no significant adaptations. While no clinical risk factors (i.e., hypertension, dyslipidemia, or systemic inflammation) emerged pertaining to the development of cardiovascular disease, we identified impaired endothelium-dependent and -independent arteriolar dysfunction and cardiac morphological alterations consistent with myocardial inflammation, degeneration, and necrosis in exposed progeny at 12 months. In conclusion, maternal inhalation of nano-TiO2 aerosols during gestation may promote the development of coronary disease in adult offspring.Sara B. FournierVincent LamMichael J. GoedkenLaura FabrisPhoebe A. StapletonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sara B. Fournier Vincent Lam Michael J. Goedken Laura Fabris Phoebe A. Stapleton Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation
description	Abstract Maternal exposure to environmental contaminants during pregnancy can profoundly influence the risk of developing cardiovascular disease in adult offspring. Our previous studies have demonstrated impaired cardiovascular health, microvascular reactivity, and cardiac function in fetal and young adult progeny after maternal inhalation of nano-sized titanium dioxide (nano-TiO2) aerosols during gestation. The present study was designed to evaluate the development of cardiovascular and metabolic diseases later in adulthood. Pregnant Sprague–Dawley rats were exposed to nano-TiO2 aerosols (~ 10 mg/m3, 134 nm median diameter) for 4 h per day, 5 days per week, beginning on gestational day (GD) 4 and ending on GD 19. Progeny were delivered in-house. Body weight was recorded weekly after birth. After 47 weeks, the body weight of exposed progeny was 9.4% greater compared with controls. Heart weight, mean arterial pressure, and plasma biomarkers of inflammation, dyslipidemia, and glycemic control were recorded at 3, 9 and 12 months of age, with no significant adaptations. While no clinical risk factors (i.e., hypertension, dyslipidemia, or systemic inflammation) emerged pertaining to the development of cardiovascular disease, we identified impaired endothelium-dependent and -independent arteriolar dysfunction and cardiac morphological alterations consistent with myocardial inflammation, degeneration, and necrosis in exposed progeny at 12 months. In conclusion, maternal inhalation of nano-TiO2 aerosols during gestation may promote the development of coronary disease in adult offspring.
format	article
author	Sara B. Fournier Vincent Lam Michael J. Goedken Laura Fabris Phoebe A. Stapleton
author_facet	Sara B. Fournier Vincent Lam Michael J. Goedken Laura Fabris Phoebe A. Stapleton
author_sort	Sara B. Fournier
title	Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation
title_short	Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation
title_full	Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation
title_fullStr	Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation
title_full_unstemmed	Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation
title_sort	development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f0fb8d62429c4deaa38b111461f5ee6c
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Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation

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