Traveling Theta Waves and the Hippocampal Phase Code

Abstract Hippocampal place fields form a neuronal map of the spatial environment. In addition, the distance between two place field centers is proportional to the firing phase difference of two place cells with respect to the local theta rhythm. This consistency between spatial distance and theta ph...

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Autores principales:	Christian Leibold, Mauro M. Monsalve-Mercado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f0fd8ee024e5439b886d82774f5857ee
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id	oai:doaj.org-article:f0fd8ee024e5439b886d82774f5857ee
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spelling	oai:doaj.org-article:f0fd8ee024e5439b886d82774f5857ee2021-12-02T15:06:22ZTraveling Theta Waves and the Hippocampal Phase Code10.1038/s41598-017-08053-32045-2322https://doaj.org/article/f0fd8ee024e5439b886d82774f5857ee2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08053-3https://doaj.org/toc/2045-2322Abstract Hippocampal place fields form a neuronal map of the spatial environment. In addition, the distance between two place field centers is proportional to the firing phase difference of two place cells with respect to the local theta rhythm. This consistency between spatial distance and theta phase is generally assumed to result from hippocampal phase precession: The firing phase of a place cell decreases with distance traveled in the place field. The rate of phase precession depends on place field width such that the phase range covered in a traversal of a place field is independent of field width. Width-dependent precession rates, however, generally disrupt the consistency between distance and phase differences. In this paper we provide a mathematical theory suggesting that this consistency can only be secured for different place field widths if phase precession starts at a width-dependent phase offset. These offsets are in accordance with the experimentally observed theta wave traveling from the dorsal to the ventral pole of the hippocampus. Furthermore the theory predicts that sequences of place cells with different widths should be ordered according to the end of the place field. The results also hold for considerably nonlinear phase precession profiles.Christian LeiboldMauro M. Monsalve-MercadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian Leibold Mauro M. Monsalve-Mercado Traveling Theta Waves and the Hippocampal Phase Code
description	Abstract Hippocampal place fields form a neuronal map of the spatial environment. In addition, the distance between two place field centers is proportional to the firing phase difference of two place cells with respect to the local theta rhythm. This consistency between spatial distance and theta phase is generally assumed to result from hippocampal phase precession: The firing phase of a place cell decreases with distance traveled in the place field. The rate of phase precession depends on place field width such that the phase range covered in a traversal of a place field is independent of field width. Width-dependent precession rates, however, generally disrupt the consistency between distance and phase differences. In this paper we provide a mathematical theory suggesting that this consistency can only be secured for different place field widths if phase precession starts at a width-dependent phase offset. These offsets are in accordance with the experimentally observed theta wave traveling from the dorsal to the ventral pole of the hippocampus. Furthermore the theory predicts that sequences of place cells with different widths should be ordered according to the end of the place field. The results also hold for considerably nonlinear phase precession profiles.
format	article
author	Christian Leibold Mauro M. Monsalve-Mercado
author_facet	Christian Leibold Mauro M. Monsalve-Mercado
author_sort	Christian Leibold
title	Traveling Theta Waves and the Hippocampal Phase Code
title_short	Traveling Theta Waves and the Hippocampal Phase Code
title_full	Traveling Theta Waves and the Hippocampal Phase Code
title_fullStr	Traveling Theta Waves and the Hippocampal Phase Code
title_full_unstemmed	Traveling Theta Waves and the Hippocampal Phase Code
title_sort	traveling theta waves and the hippocampal phase code
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f0fd8ee024e5439b886d82774f5857ee
work_keys_str_mv	AT christianleibold travelingthetawavesandthehippocampalphasecode AT maurommonsalvemercado travelingthetawavesandthehippocampalphasecode
_version_	1718388488555986944

Traveling Theta Waves and the Hippocampal Phase Code

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