Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by a progressive loss of visual function that primarily affect photoreceptors, resulting in the complete disorganization and remodeling of the retina. Progression of the disease is enhanced by increased oxidat...

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Autores principales:	Lorena Fuentes-Broto, Lorena Perdices, Francisco Segura, Elvira Orduna-Hospital, Gema Insa-Sánchez, Ana I. Sánchez-Cano, Nicolás Cuenca, Isabel Pinilla
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	retinitis pigmentosa antioxidant melatonin oxidative stress neurodegeneration circadian rhythms Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f0fecee3be354a1c80ad653ef940b686
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spelling	oai:doaj.org-article:f0fecee3be354a1c80ad653ef940b6862021-11-25T16:29:53ZEffects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa10.3390/antiox101118532076-3921https://doaj.org/article/f0fecee3be354a1c80ad653ef940b6862021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1853https://doaj.org/toc/2076-3921Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by a progressive loss of visual function that primarily affect photoreceptors, resulting in the complete disorganization and remodeling of the retina. Progression of the disease is enhanced by increased oxidative stress in the retina, aqueous humor, plasma, and liver of RP animal models and patients. Melatonin has beneficial effects against age-related macular degeneration, glaucoma, and diabetic retinopathy, in which oxidative stress plays a key role. In the present study, we used the P23HxLE rat as an animal model of RP. Melatonin treatment (10 mg/kg b.w. daily in drinking water for 6 months) improved the parameters of visual function and decreased the rate of desynchronization of the circadian rhythm, both in P23HxLE and wild-type rats. Melatonin reduced oxidative stress and increased antioxidant defenses in P23HxLE animals. In wild-type animals, melatonin did not modify any of the oxidative stress markers analyzed and reduced the levels of total antioxidant defenses. Treatment with melatonin improved visual function, circadian synchronization, and hepatic oxidative stress in P23HxLE rats, an RP model, and had beneficial effects against age-related visual damage in wild-type rats.Lorena Fuentes-BrotoLorena PerdicesFrancisco SeguraElvira Orduna-HospitalGema Insa-SánchezAna I. Sánchez-CanoNicolás CuencaIsabel PinillaMDPI AGarticleretinitis pigmentosaantioxidantmelatoninoxidative stressneurodegenerationcircadian rhythmsTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1853, p 1853 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinitis pigmentosa antioxidant melatonin oxidative stress neurodegeneration circadian rhythms Therapeutics. Pharmacology RM1-950
spellingShingle	retinitis pigmentosa antioxidant melatonin oxidative stress neurodegeneration circadian rhythms Therapeutics. Pharmacology RM1-950 Lorena Fuentes-Broto Lorena Perdices Francisco Segura Elvira Orduna-Hospital Gema Insa-Sánchez Ana I. Sánchez-Cano Nicolás Cuenca Isabel Pinilla Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa
description	Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by a progressive loss of visual function that primarily affect photoreceptors, resulting in the complete disorganization and remodeling of the retina. Progression of the disease is enhanced by increased oxidative stress in the retina, aqueous humor, plasma, and liver of RP animal models and patients. Melatonin has beneficial effects against age-related macular degeneration, glaucoma, and diabetic retinopathy, in which oxidative stress plays a key role. In the present study, we used the P23HxLE rat as an animal model of RP. Melatonin treatment (10 mg/kg b.w. daily in drinking water for 6 months) improved the parameters of visual function and decreased the rate of desynchronization of the circadian rhythm, both in P23HxLE and wild-type rats. Melatonin reduced oxidative stress and increased antioxidant defenses in P23HxLE animals. In wild-type animals, melatonin did not modify any of the oxidative stress markers analyzed and reduced the levels of total antioxidant defenses. Treatment with melatonin improved visual function, circadian synchronization, and hepatic oxidative stress in P23HxLE rats, an RP model, and had beneficial effects against age-related visual damage in wild-type rats.
format	article
author	Lorena Fuentes-Broto Lorena Perdices Francisco Segura Elvira Orduna-Hospital Gema Insa-Sánchez Ana I. Sánchez-Cano Nicolás Cuenca Isabel Pinilla
author_facet	Lorena Fuentes-Broto Lorena Perdices Francisco Segura Elvira Orduna-Hospital Gema Insa-Sánchez Ana I. Sánchez-Cano Nicolás Cuenca Isabel Pinilla
author_sort	Lorena Fuentes-Broto
title	Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa
title_short	Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa
title_full	Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa
title_fullStr	Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa
title_full_unstemmed	Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa
title_sort	effects of daily melatonin supplementation on visual loss, circadian rhythms, and hepatic oxidative damage in a rodent model of retinitis pigmentosa
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f0fecee3be354a1c80ad653ef940b686
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Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa

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