Intra- and inter-protein couplings of backbone motions underlie protein thiol-disulfide exchange cascade

Abstract The thioredoxin (Trx)-coupled arsenate reductase (ArsC) is a family of enzymes that catalyzes the reduction of arsenate to arsenite in the arsenic detoxification pathway. The catalytic cycle involves a series of relayed intramolecular and intermolecular thiol-disulfide exchange reactions. S...

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Bibliographic Details
Main Authors: Wenbo Zhang, Xiaogang Niu, Jienv Ding, Yunfei Hu, Changwen Jin
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
R
Q
Online Access:https://doaj.org/article/f107f36c806848fe9ba43bb176dbaf44
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