Microvascular stasis and hemolysis: coincidence or causality?

Katharina Effenberger-Neidnicht,1 Simon Bornmann,1 Johannes Jägers,2 Vivien Patyk,1 Michael Kirsch11Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 2Institute of Physiology, University Hospital Essen, Essen, GermanyMicrovascular stasis in course of sepsis mi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Effenberger-Neidnicht K, Bornmann S, Jägers J, Patyk V, Kirsch M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Lipopolysaccharide – capillary congestion – blood accumulation – cell-free hemoglobin – microcirculation – intestine Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f1096678add6415892ea4b65ad094ad8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f1096678add6415892ea4b65ad094ad8
record_format	dspace
spelling	oai:doaj.org-article:f1096678add6415892ea4b65ad094ad82021-12-02T05:31:12ZMicrovascular stasis and hemolysis: coincidence or causality?1178-7031https://doaj.org/article/f1096678add6415892ea4b65ad094ad82019-05-01T00:00:00Zhttps://www.dovepress.com/microvascular-stasis-and-hemolysis-coincidence-or-causality-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Katharina Effenberger-Neidnicht,1 Simon Bornmann,1 Johannes Jägers,2 Vivien Patyk,1 Michael Kirsch11Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 2Institute of Physiology, University Hospital Essen, Essen, GermanyMicrovascular stasis in course of sepsis might be a consequence of hemolysisThere are various studies demonstrating that hemolysis or the presence of cell-free hemoglobin and heme causes microvascular stasis (Figure 1). Buurman and his team of researchers already showed that acute hemolysis (with plasma levels of cfHb ~20–30 μmol/L) – induced by infusion of water or pre-lysed red blood cells – was associated with an impaired renal, hepatic and intestinal microvasculature.2 They further showed that intraoperative hemolysis (with plasma levels of cfHb ~20 μmol/L) during major aortic surgery was associated with postoperative acute kidney injury.3 The offset times between occurring hemolysis and intestinal microvascular changes or renal microvascular changes were approximately 15–30 mins2 respective 120 mins3. Moreover, Vinchi and co-workers could reduce liver damage in a mouse model of heme overload in wild-type mice compared to hemopexin-null mice.4 They concluded that hemopexin prevents from hemolysis-induced hepatic microvascular stasis.4 Belcher et al compared different treatments to induce hemolysis and heme overload (eg, infusion of water, hemoglobin or heme) in transgenic sickle mice and found a relationship between microvascular stasis and total plasma heme concentrations (with plasma levels of heme ~25–80 μmol/L).5 They further proved that intravascular hemolysis during sickle cell disease elicits microvascular stasis via Toll-like receptor 4 signaling.5 Further studies of the researchers around Belcher and Vercellotti showed inhibition of hemoglobin-induced microvascular stasis in transgenic sickle mice by hemopexin and haptoglobin supplementation,6 overexpression of hemopexin7 or overexpression of ferritin heavy chain ferrioxidase.8Effenberger-Neidnicht KBornmann SJägers JPatyk VKirsch MDove Medical PressarticleLipopolysaccharide – capillary congestion – blood accumulation – cell-free hemoglobin – microcirculation – intestinePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 12, Pp 109-111 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lipopolysaccharide – capillary congestion – blood accumulation – cell-free hemoglobin – microcirculation – intestine Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Lipopolysaccharide – capillary congestion – blood accumulation – cell-free hemoglobin – microcirculation – intestine Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Effenberger-Neidnicht K Bornmann S Jägers J Patyk V Kirsch M Microvascular stasis and hemolysis: coincidence or causality?
description	Katharina Effenberger-Neidnicht,1 Simon Bornmann,1 Johannes Jägers,2 Vivien Patyk,1 Michael Kirsch11Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 2Institute of Physiology, University Hospital Essen, Essen, GermanyMicrovascular stasis in course of sepsis might be a consequence of hemolysisThere are various studies demonstrating that hemolysis or the presence of cell-free hemoglobin and heme causes microvascular stasis (Figure 1). Buurman and his team of researchers already showed that acute hemolysis (with plasma levels of cfHb ~20–30 μmol/L) – induced by infusion of water or pre-lysed red blood cells – was associated with an impaired renal, hepatic and intestinal microvasculature.2 They further showed that intraoperative hemolysis (with plasma levels of cfHb ~20 μmol/L) during major aortic surgery was associated with postoperative acute kidney injury.3 The offset times between occurring hemolysis and intestinal microvascular changes or renal microvascular changes were approximately 15–30 mins2 respective 120 mins3. Moreover, Vinchi and co-workers could reduce liver damage in a mouse model of heme overload in wild-type mice compared to hemopexin-null mice.4 They concluded that hemopexin prevents from hemolysis-induced hepatic microvascular stasis.4 Belcher et al compared different treatments to induce hemolysis and heme overload (eg, infusion of water, hemoglobin or heme) in transgenic sickle mice and found a relationship between microvascular stasis and total plasma heme concentrations (with plasma levels of heme ~25–80 μmol/L).5 They further proved that intravascular hemolysis during sickle cell disease elicits microvascular stasis via Toll-like receptor 4 signaling.5 Further studies of the researchers around Belcher and Vercellotti showed inhibition of hemoglobin-induced microvascular stasis in transgenic sickle mice by hemopexin and haptoglobin supplementation,6 overexpression of hemopexin7 or overexpression of ferritin heavy chain ferrioxidase.8
format	article
author	Effenberger-Neidnicht K Bornmann S Jägers J Patyk V Kirsch M
author_facet	Effenberger-Neidnicht K Bornmann S Jägers J Patyk V Kirsch M
author_sort	Effenberger-Neidnicht K
title	Microvascular stasis and hemolysis: coincidence or causality?
title_short	Microvascular stasis and hemolysis: coincidence or causality?
title_full	Microvascular stasis and hemolysis: coincidence or causality?
title_fullStr	Microvascular stasis and hemolysis: coincidence or causality?
title_full_unstemmed	Microvascular stasis and hemolysis: coincidence or causality?
title_sort	microvascular stasis and hemolysis: coincidence or causality?
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f1096678add6415892ea4b65ad094ad8
work_keys_str_mv	AT effenbergerneidnichtk microvascularstasisandhemolysiscoincidenceorcausality AT bornmanns microvascularstasisandhemolysiscoincidenceorcausality AT jagersj microvascularstasisandhemolysiscoincidenceorcausality AT patykv microvascularstasisandhemolysiscoincidenceorcausality AT kirschm microvascularstasisandhemolysiscoincidenceorcausality
_version_	1718400387951624192

Microvascular stasis and hemolysis: coincidence or causality?

Ejemplares similares