Dynamic structural states of ClpB involved in its disaggregation function

The bacterial protein disaggregation machine ClpB uses ATP to generate mechanical force to unfold and thread its protein substrates. Here authors visualize the ClpB ring using high-speed atomic force microscopy and capture conformational changes of the hexameric ring during the ATPase reaction.

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Autores principales:	Takayuki Uchihashi, Yo-hei Watanabe, Yosuke Nakazaki, Takashi Yamasaki, Hiroki Watanabe, Takahiro Maruno, Kentaro Ishii, Susumu Uchiyama, Chihong Song, Kazuyoshi Murata, Ryota Iino, Toshio Ando
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f10a7d63f3934077acd63c3f83c2cc21
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spelling	oai:doaj.org-article:f10a7d63f3934077acd63c3f83c2cc212021-12-02T14:41:29ZDynamic structural states of ClpB involved in its disaggregation function10.1038/s41467-018-04587-w2041-1723https://doaj.org/article/f10a7d63f3934077acd63c3f83c2cc212018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04587-whttps://doaj.org/toc/2041-1723The bacterial protein disaggregation machine ClpB uses ATP to generate mechanical force to unfold and thread its protein substrates. Here authors visualize the ClpB ring using high-speed atomic force microscopy and capture conformational changes of the hexameric ring during the ATPase reaction.Takayuki UchihashiYo-hei WatanabeYosuke NakazakiTakashi YamasakiHiroki WatanabeTakahiro MarunoKentaro IshiiSusumu UchiyamaChihong SongKazuyoshi MurataRyota IinoToshio AndoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takayuki Uchihashi Yo-hei Watanabe Yosuke Nakazaki Takashi Yamasaki Hiroki Watanabe Takahiro Maruno Kentaro Ishii Susumu Uchiyama Chihong Song Kazuyoshi Murata Ryota Iino Toshio Ando Dynamic structural states of ClpB involved in its disaggregation function
description	The bacterial protein disaggregation machine ClpB uses ATP to generate mechanical force to unfold and thread its protein substrates. Here authors visualize the ClpB ring using high-speed atomic force microscopy and capture conformational changes of the hexameric ring during the ATPase reaction.
format	article
author	Takayuki Uchihashi Yo-hei Watanabe Yosuke Nakazaki Takashi Yamasaki Hiroki Watanabe Takahiro Maruno Kentaro Ishii Susumu Uchiyama Chihong Song Kazuyoshi Murata Ryota Iino Toshio Ando
author_facet	Takayuki Uchihashi Yo-hei Watanabe Yosuke Nakazaki Takashi Yamasaki Hiroki Watanabe Takahiro Maruno Kentaro Ishii Susumu Uchiyama Chihong Song Kazuyoshi Murata Ryota Iino Toshio Ando
author_sort	Takayuki Uchihashi
title	Dynamic structural states of ClpB involved in its disaggregation function
title_short	Dynamic structural states of ClpB involved in its disaggregation function
title_full	Dynamic structural states of ClpB involved in its disaggregation function
title_fullStr	Dynamic structural states of ClpB involved in its disaggregation function
title_full_unstemmed	Dynamic structural states of ClpB involved in its disaggregation function
title_sort	dynamic structural states of clpb involved in its disaggregation function
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f10a7d63f3934077acd63c3f83c2cc21
work_keys_str_mv	AT takayukiuchihashi dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT yoheiwatanabe dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT yosukenakazaki dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT takashiyamasaki dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT hirokiwatanabe dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT takahiromaruno dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT kentaroishii dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT susumuuchiyama dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT chihongsong dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT kazuyoshimurata dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT ryotaiino dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction AT toshioando dynamicstructuralstatesofclpbinvolvedinitsdisaggregationfunction
_version_	1718389906469814272

Dynamic structural states of ClpB involved in its disaggregation function

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