Pneumococcal polysaccharide abrogates conjugate-induced germinal center reaction and depletes antibody secreting cell pool, causing hyporesponsiveness.

<h4>Background</h4>Plain pneumococcal polysaccharide (PPS) booster administered during second year of life has been shown to cause hyporesponsiveness. We assessed the effects of PPS booster on splenic memory B cell responses and persistence of PPS-specific long-lived plasma cells in the...

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Autores principales: Stefania P Bjarnarson, Hreinn Benonisson, Giuseppe Del Giudice, Ingileif Jonsdottir
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/f10eeacfa7784a39a74b7409afe35bcd
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