Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices

Abstract The difficulty in translating conventional microfluidics from laboratory prototypes to commercial products has shifted research efforts towards thermoplastic materials for their higher translational potential and amenability to industrial manufacturing. Here, we present an accessible method...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carlos Matellan, Armando E. del Río Hernández
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f110de66e9ac47589e8e3f2b404b0c6a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f110de66e9ac47589e8e3f2b404b0c6a
record_format	dspace
spelling	oai:doaj.org-article:f110de66e9ac47589e8e3f2b404b0c6a2021-12-02T15:06:06ZCost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices10.1038/s41598-018-25202-42045-2322https://doaj.org/article/f110de66e9ac47589e8e3f2b404b0c6a2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25202-4https://doaj.org/toc/2045-2322Abstract The difficulty in translating conventional microfluidics from laboratory prototypes to commercial products has shifted research efforts towards thermoplastic materials for their higher translational potential and amenability to industrial manufacturing. Here, we present an accessible method to fabricate and assemble polymethyl methacrylate (PMMA) microfluidic devices in a “mask-less” and cost-effective manner that can be applied to manufacture a wide range of designs due to its versatility. Laser micromachining offers high flexibility in channel dimensions and morphology by controlling the laser properties, while our two-step surface treatment based on exposure to acetone vapour and low-temperature annealing enables improvement of the surface quality without deformation of the device. Finally, we demonstrate a capillarity-driven adhesive delivery bonding method that can produce an effective seal between PMMA devices and a variety of substrates, including glass, silicon and LiNbO3. We illustrate the potential of this technique with two microfluidic devices, an H-filter and a droplet generator. The technique proposed here offers a low entry barrier for the rapid prototyping of thermoplastic microfluidics, enabling iterative design for laboratories without access to conventional microfabrication equipment.Carlos MatellanArmando E. del Río HernándezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carlos Matellan Armando E. del Río Hernández Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices
description	Abstract The difficulty in translating conventional microfluidics from laboratory prototypes to commercial products has shifted research efforts towards thermoplastic materials for their higher translational potential and amenability to industrial manufacturing. Here, we present an accessible method to fabricate and assemble polymethyl methacrylate (PMMA) microfluidic devices in a “mask-less” and cost-effective manner that can be applied to manufacture a wide range of designs due to its versatility. Laser micromachining offers high flexibility in channel dimensions and morphology by controlling the laser properties, while our two-step surface treatment based on exposure to acetone vapour and low-temperature annealing enables improvement of the surface quality without deformation of the device. Finally, we demonstrate a capillarity-driven adhesive delivery bonding method that can produce an effective seal between PMMA devices and a variety of substrates, including glass, silicon and LiNbO3. We illustrate the potential of this technique with two microfluidic devices, an H-filter and a droplet generator. The technique proposed here offers a low entry barrier for the rapid prototyping of thermoplastic microfluidics, enabling iterative design for laboratories without access to conventional microfabrication equipment.
format	article
author	Carlos Matellan Armando E. del Río Hernández
author_facet	Carlos Matellan Armando E. del Río Hernández
author_sort	Carlos Matellan
title	Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices
title_short	Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices
title_full	Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices
title_fullStr	Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices
title_full_unstemmed	Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices
title_sort	cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f110de66e9ac47589e8e3f2b404b0c6a
work_keys_str_mv	AT carlosmatellan costeffectiverapidprototypingandassemblyofpolymethylmethacrylatemicrofluidicdevices AT armandoedelriohernandez costeffectiverapidprototypingandassemblyofpolymethylmethacrylatemicrofluidicdevices
_version_	1718388617765715968

Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices

Ejemplares similares