Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler

HF Salem1 ME Abdelrahim2 K Abo Eid3 MA Sharaf3,41Department of Pharmaceutics, 2Department of Clinical Pharmacy, Faculty of Pharmacy, The University of Beni Suef, Beni Suef; 3Department of Chemistry, Helwan University, Ain Helwan, Helwan, Egypt; 4Department of Chemistry, The American University in Ca...

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Autores principales:	HF Salem, ME Abdelrahim, K Abo Eid, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f112b3e791ac45a38d8937c919bf0523
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spelling	oai:doaj.org-article:f112b3e791ac45a38d8937c919bf05232021-12-02T01:07:54ZNanosized rods agglomerates as a new approach for formulation of a dry powder inhaler1176-91141178-2013https://doaj.org/article/f112b3e791ac45a38d8937c919bf05232011-02-01T00:00:00Zhttp://www.dovepress.com/nanosized-rods-agglomerates-as-a-new-approach-for-formulation-of-a-dry-a6223https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013HF Salem1 ME Abdelrahim2 K Abo Eid3 MA Sharaf3,41Department of Pharmaceutics, 2Department of Clinical Pharmacy, Faculty of Pharmacy, The University of Beni Suef, Beni Suef; 3Department of Chemistry, Helwan University, Ain Helwan, Helwan, Egypt; 4Department of Chemistry, The American University in Cairo, New Cairo, Helwan 11835, EgyptBackground: Nanosized dry powder inhalers provide higher stability for poorly water-soluble drugs as compared with liquid formulations. However, the respirable particles must have a diameter of 1&ndash;5 &micro;m in order to deposit in the lungs. Controlled agglomeration of the nanoparticles increases their geometric particle size so they can deposit easily in the lungs. In the lungs, they fall apart to reform nanoparticles, thus enhancing the dissolution rate of the drugs. Theophylline is a bronchodilator with poor solubility in water.Methods: Nanosized theophylline colloids were formed using an amphiphilic surfactant and destabilized using dilute sodium chloride solutions to form the agglomerates.Results: The theophylline nanoparticles thus obtained had an average particle size of 290 nm and a zeta potential of &minus;39.5 mV, whereas the agglomerates were 2.47 &micro;m in size with a zeta potential of &minus;28.9 mV. The release profile was found to follow first-order kinetics (r2 &gt; 0.96). The aerodynamic characteristics of the agglomerated nanoparticles were determined using a cascade impactor. The behavior of the agglomerate was significantly better than unprocessed raw theophylline powder. In addition, the nanoparticles and agglomerates resulted in a significant improvement in the dissolution of theophylline.Conclusion: The results obtained lend support to the hypothesis that controlled agglomeration strategies provide an efficient approach for the delivery of poorly water-soluble drugs into the lungs.Keywords: theophylline, nanoparticles, agglomerates, dry powder inhaler HF SalemME AbdelrahimK Abo Eidet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 311-320 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 HF Salem ME Abdelrahim K Abo Eid et al Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler
description	HF Salem1 ME Abdelrahim2 K Abo Eid3 MA Sharaf3,41Department of Pharmaceutics, 2Department of Clinical Pharmacy, Faculty of Pharmacy, The University of Beni Suef, Beni Suef; 3Department of Chemistry, Helwan University, Ain Helwan, Helwan, Egypt; 4Department of Chemistry, The American University in Cairo, New Cairo, Helwan 11835, EgyptBackground: Nanosized dry powder inhalers provide higher stability for poorly water-soluble drugs as compared with liquid formulations. However, the respirable particles must have a diameter of 1&ndash;5 &micro;m in order to deposit in the lungs. Controlled agglomeration of the nanoparticles increases their geometric particle size so they can deposit easily in the lungs. In the lungs, they fall apart to reform nanoparticles, thus enhancing the dissolution rate of the drugs. Theophylline is a bronchodilator with poor solubility in water.Methods: Nanosized theophylline colloids were formed using an amphiphilic surfactant and destabilized using dilute sodium chloride solutions to form the agglomerates.Results: The theophylline nanoparticles thus obtained had an average particle size of 290 nm and a zeta potential of &minus;39.5 mV, whereas the agglomerates were 2.47 &micro;m in size with a zeta potential of &minus;28.9 mV. The release profile was found to follow first-order kinetics (r2 &gt; 0.96). The aerodynamic characteristics of the agglomerated nanoparticles were determined using a cascade impactor. The behavior of the agglomerate was significantly better than unprocessed raw theophylline powder. In addition, the nanoparticles and agglomerates resulted in a significant improvement in the dissolution of theophylline.Conclusion: The results obtained lend support to the hypothesis that controlled agglomeration strategies provide an efficient approach for the delivery of poorly water-soluble drugs into the lungs.Keywords: theophylline, nanoparticles, agglomerates, dry powder inhaler
format	article
author	HF Salem ME Abdelrahim K Abo Eid et al
author_facet	HF Salem ME Abdelrahim K Abo Eid et al
author_sort	HF Salem
title	Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler
title_short	Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler
title_full	Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler
title_fullStr	Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler
title_full_unstemmed	Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler
title_sort	nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/f112b3e791ac45a38d8937c919bf0523
work_keys_str_mv	AT hfsalem nanosizedrodsagglomeratesasanewapproachforformulationofadrypowderinhaler AT meabdelrahim nanosizedrodsagglomeratesasanewapproachforformulationofadrypowderinhaler AT kaboeid nanosizedrodsagglomeratesasanewapproachforformulationofadrypowderinhaler AT etal nanosizedrodsagglomeratesasanewapproachforformulationofadrypowderinhaler
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Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler

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