Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care

Abstract Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c...

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Autores principales:	Matheus Augusto Soares de Resende, Emily de Souza Ferreira, Heloísa Helena Dias, Daniel Souza Santos, Clara Regina Santos Batistelli, Luiza Delazari Borges, Luma de Oliveira Comini, Tiago Ricardo Moreira, Glauce Dias da Costa, Eunice Ferreira da Silva, Rodrigo Gomes da Silva, Rosângela Minardi Mitre Cotta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f114125467044493a2fe247a86fc6301
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spelling	oai:doaj.org-article:f114125467044493a2fe247a86fc63012021-12-02T17:51:16ZLow-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care10.1038/s41598-021-96652-62045-2322https://doaj.org/article/f114125467044493a2fe247a86fc63012021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96652-6https://doaj.org/toc/2045-2322Abstract Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) with LGA. Our study aimed to investigate and compare the association of HbA1c and FPG with the probability of LGA in adult and elderly individuals with DM and AH, within the scope of Primary Health Care (PHC). Cross-sectional study involving 737 Brazilians individuals previously diagnosed with hypertension and/or diabetes. Tests for HbA1c, FPG and LGA were performed. LGA was defined as the highest quartile of albumin urinary (≥ 13 mg/g) among individuals with urinary LGA < 30 mg / g. A significant increase in the prevalence of LGA was found with increasing levels of HbA1c (p < 0.001). There was a significant association of HbA1c with LGA (p < 0.001) and increased probability of LGA for participants with HbA1c ≥ 6.5% compared to those with Hba1c < 5.7% (OR [95% CI]: 2.43 [1.32–4.46], p < 0.05), after adjusting for confounding factors, except when adjusted for FPG (p = 0.379 and p = 0.359, respectively). HbA1c and FPG were significantly associated in a collinear manner with an increased probability of LGA in adult and elderly individuals with DM and AH.Matheus Augusto Soares de ResendeEmily de Souza FerreiraHeloísa Helena DiasDaniel Souza SantosClara Regina Santos BatistelliLuiza Delazari BorgesLuma de Oliveira CominiTiago Ricardo MoreiraGlauce Dias da CostaEunice Ferreira da SilvaRodrigo Gomes da SilvaRosângela Minardi Mitre CottaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matheus Augusto Soares de Resende Emily de Souza Ferreira Heloísa Helena Dias Daniel Souza Santos Clara Regina Santos Batistelli Luiza Delazari Borges Luma de Oliveira Comini Tiago Ricardo Moreira Glauce Dias da Costa Eunice Ferreira da Silva Rodrigo Gomes da Silva Rosângela Minardi Mitre Cotta Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
description	Abstract Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) with LGA. Our study aimed to investigate and compare the association of HbA1c and FPG with the probability of LGA in adult and elderly individuals with DM and AH, within the scope of Primary Health Care (PHC). Cross-sectional study involving 737 Brazilians individuals previously diagnosed with hypertension and/or diabetes. Tests for HbA1c, FPG and LGA were performed. LGA was defined as the highest quartile of albumin urinary (≥ 13 mg/g) among individuals with urinary LGA < 30 mg / g. A significant increase in the prevalence of LGA was found with increasing levels of HbA1c (p < 0.001). There was a significant association of HbA1c with LGA (p < 0.001) and increased probability of LGA for participants with HbA1c ≥ 6.5% compared to those with Hba1c < 5.7% (OR [95% CI]: 2.43 [1.32–4.46], p < 0.05), after adjusting for confounding factors, except when adjusted for FPG (p = 0.379 and p = 0.359, respectively). HbA1c and FPG were significantly associated in a collinear manner with an increased probability of LGA in adult and elderly individuals with DM and AH.
format	article
author	Matheus Augusto Soares de Resende Emily de Souza Ferreira Heloísa Helena Dias Daniel Souza Santos Clara Regina Santos Batistelli Luiza Delazari Borges Luma de Oliveira Comini Tiago Ricardo Moreira Glauce Dias da Costa Eunice Ferreira da Silva Rodrigo Gomes da Silva Rosângela Minardi Mitre Cotta
author_facet	Matheus Augusto Soares de Resende Emily de Souza Ferreira Heloísa Helena Dias Daniel Souza Santos Clara Regina Santos Batistelli Luiza Delazari Borges Luma de Oliveira Comini Tiago Ricardo Moreira Glauce Dias da Costa Eunice Ferreira da Silva Rodrigo Gomes da Silva Rosângela Minardi Mitre Cotta
author_sort	Matheus Augusto Soares de Resende
title	Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_short	Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_full	Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_fullStr	Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_full_unstemmed	Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_sort	low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by primary health care
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f114125467044493a2fe247a86fc6301
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Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care

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