Biologics: the role of delivery systems in improved therapy
Nataša Škalko-Basnet Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø, Tromsø, Norway Abstract: The beginning of the 21st century saw numerous protein and peptide therapeuticals both on the market and entering the...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f117b9a38fdf4a7aaf5c023cb9a80457 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f117b9a38fdf4a7aaf5c023cb9a80457 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f117b9a38fdf4a7aaf5c023cb9a804572021-12-02T02:11:04ZBiologics: the role of delivery systems in improved therapy1177-5475https://doaj.org/article/f117b9a38fdf4a7aaf5c023cb9a804572014-03-01T00:00:00Zhttp://www.dovepress.com/biologics-the-role-of-delivery-systems-in-improved-therapy-a16161https://doaj.org/toc/1177-5475 Nataša Škalko-Basnet Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø, Tromsø, Norway Abstract: The beginning of the 21st century saw numerous protein and peptide therapeuticals both on the market and entering the final stages of clinical studies. They represent a new category of biologically originated drugs termed biologics or biologicals. Their main advantages over conventional drugs can be summarized by their high selectivity and potent therapeutic efficacy coupled with limited side effects. In addition, they exhibit more predictable behavior under in vivo conditions. However, up to now most of the formulations of biologics are designed and destined for the parenteral route of administration. As a consequence, many suffer from short plasma half-lives, resulting in their frequent administration and ultimately poor patient compliance. This review represents an attempt to address some of the challenges and promises in the product development of biologics both for parenteral and noninvasive administration. Some of the products currently in the pipeline of pharmaceutical development and corresponding perspectives are discussed in more detail. Keywords: biologics, drug delivery systems, medical devicesŠkalko-Basnet NDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2014, Iss default, Pp 107-114 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Škalko-Basnet N Biologics: the role of delivery systems in improved therapy |
| description |
Nataša Škalko-Basnet Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø, Tromsø, Norway Abstract: The beginning of the 21st century saw numerous protein and peptide therapeuticals both on the market and entering the final stages of clinical studies. They represent a new category of biologically originated drugs termed biologics or biologicals. Their main advantages over conventional drugs can be summarized by their high selectivity and potent therapeutic efficacy coupled with limited side effects. In addition, they exhibit more predictable behavior under in vivo conditions. However, up to now most of the formulations of biologics are designed and destined for the parenteral route of administration. As a consequence, many suffer from short plasma half-lives, resulting in their frequent administration and ultimately poor patient compliance. This review represents an attempt to address some of the challenges and promises in the product development of biologics both for parenteral and noninvasive administration. Some of the products currently in the pipeline of pharmaceutical development and corresponding perspectives are discussed in more detail. Keywords: biologics, drug delivery systems, medical devices |
| format |
article |
| author |
Škalko-Basnet N |
| author_facet |
Škalko-Basnet N |
| author_sort |
Škalko-Basnet N |
| title |
Biologics: the role of delivery systems in improved therapy |
| title_short |
Biologics: the role of delivery systems in improved therapy |
| title_full |
Biologics: the role of delivery systems in improved therapy |
| title_fullStr |
Biologics: the role of delivery systems in improved therapy |
| title_full_unstemmed |
Biologics: the role of delivery systems in improved therapy |
| title_sort |
biologics: the role of delivery systems in improved therapy |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/f117b9a38fdf4a7aaf5c023cb9a80457 |
| work_keys_str_mv |
AT scaronkalkobasnetn biologicstheroleofdeliverysystemsinimprovedtherapy |
| _version_ |
1718402686334795776 |