E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to germline genes during early mouse development.

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Detalles Bibliográficos
Autores principales: Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anaïs F. Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N. Robinson, Christian Hagemeier, Michael Weber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/f118f417497a4386a18456d4d7889a0a
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Sumario:DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to germline genes during early mouse development.

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