E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to germline genes during early mouse development.

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Autores principales:	Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anaïs F. Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N. Robinson, Christian Hagemeier, Michael Weber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f118f417497a4386a18456d4d7889a0a
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spelling	oai:doaj.org-article:f118f417497a4386a18456d4d7889a0a2021-12-02T17:52:37ZE2F6 initiates stable epigenetic silencing of germline genes during embryonic development10.1038/s41467-021-23596-w2041-1723https://doaj.org/article/f118f417497a4386a18456d4d7889a0a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23596-whttps://doaj.org/toc/2041-1723DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to germline genes during early mouse development.Thomas DahletMatthias TrussUte FredeHala Al AdhamiAnaïs F. BardetMichael DumasJudith ValletJohana ChicherPhilippe HammannSarah KottnikPeter HansenUschi LuzGonzalo AlvarezGhislain AuclairJochen HechtPeter N. RobinsonChristian HagemeierMichael WeberNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Dahlet Matthias Truss Ute Frede Hala Al Adhami Anaïs F. Bardet Michael Dumas Judith Vallet Johana Chicher Philippe Hammann Sarah Kottnik Peter Hansen Uschi Luz Gonzalo Alvarez Ghislain Auclair Jochen Hecht Peter N. Robinson Christian Hagemeier Michael Weber E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
description	DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to germline genes during early mouse development.
format	article
author	Thomas Dahlet Matthias Truss Ute Frede Hala Al Adhami Anaïs F. Bardet Michael Dumas Judith Vallet Johana Chicher Philippe Hammann Sarah Kottnik Peter Hansen Uschi Luz Gonzalo Alvarez Ghislain Auclair Jochen Hecht Peter N. Robinson Christian Hagemeier Michael Weber
author_facet	Thomas Dahlet Matthias Truss Ute Frede Hala Al Adhami Anaïs F. Bardet Michael Dumas Judith Vallet Johana Chicher Philippe Hammann Sarah Kottnik Peter Hansen Uschi Luz Gonzalo Alvarez Ghislain Auclair Jochen Hecht Peter N. Robinson Christian Hagemeier Michael Weber
author_sort	Thomas Dahlet
title	E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
title_short	E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
title_full	E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
title_fullStr	E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
title_full_unstemmed	E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
title_sort	e2f6 initiates stable epigenetic silencing of germline genes during embryonic development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f118f417497a4386a18456d4d7889a0a
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E2F6 initiates stable epigenetic silencing of germline genes during embryonic development

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