Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence

The course of attention deficit hyperactivity disorder (ADHD) from adolescence into adulthood shows large variations between individuals; nonetheless determinants of interindividual differences in the course are not well understood. A frequent problem in ADHD, associated with worse outcomes, is emot...

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Autores principales:	Tammo Viering, Pieter J. Hoekstra, Alexandra Philipsen, Jilly Naaijen, Andrea Dietrich, Catharina A. Hartman, Barbara Franke, Jan K. Buitelaar, Andrea Hildebrandt, Christiane M. Thiel, Carsten Gießing
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Attention deficit/hyperactivity disorder Emotion dysregulation Latent change score modeling Nodal efficiency Orbitofrontal cortex Resting state fmri Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f11a2e296cf54b579607c452911bf0aa
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spelling	oai:doaj.org-article:f11a2e296cf54b579607c452911bf0aa2021-12-02T04:59:32ZEmotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence1095-957210.1016/j.neuroimage.2021.118729https://doaj.org/article/f11a2e296cf54b579607c452911bf0aa2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921010016https://doaj.org/toc/1095-9572The course of attention deficit hyperactivity disorder (ADHD) from adolescence into adulthood shows large variations between individuals; nonetheless determinants of interindividual differences in the course are not well understood. A frequent problem in ADHD, associated with worse outcomes, is emotion dysregulation. We investigated whether emotion dysregulation and integration of emotion-related functional brain networks affect interindividual differences in ADHD severity change. ADHD severity and resting state neuroimaging data were measured in ADHD and unaffected individuals at two points during adolescence and young adulthood. Bivariate latent change score models were applied to investigate whether emotion dysregulation and network integration affect ADHD severity changes. Emotion dysregulation was gauged from questionnaire subscales for conduct problems, emotional problems and emotional lability. Better emotion regulation was associated with a better course of ADHD (104 participants, 44 females, age range: 12–27). Using graph analysis, we determined network integration of emotion-related functional brain networks. Network integration was measured by nodal efficiency, i.e., the average inverse path distance from one node to all other nodes. A pattern of low nodal efficiency of cortical regions associated with emotion processing and high nodal efficiency in subcortical areas and cortical areas involved in implicit emotion regulation predicted a better ADHD course. Larger nodal efficiency of the right orbitofrontal cortex was related to a better course of ADHD (99 participants, 42 females, age range: 10–29). We demonstrated that neural and behavioral covariates associated with emotion regulation affect the course of ADHD severity throughout adolescence and early adulthood beyond baseline effects of ADHD severity.Tammo VieringPieter J. HoekstraAlexandra PhilipsenJilly NaaijenAndrea DietrichCatharina A. HartmanBarbara FrankeJan K. BuitelaarAndrea HildebrandtChristiane M. ThielCarsten GießingElsevierarticleAttention deficit/hyperactivity disorderEmotion dysregulationLatent change score modelingNodal efficiencyOrbitofrontal cortexResting state fmriNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118729- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Attention deficit/hyperactivity disorder Emotion dysregulation Latent change score modeling Nodal efficiency Orbitofrontal cortex Resting state fmri Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Attention deficit/hyperactivity disorder Emotion dysregulation Latent change score modeling Nodal efficiency Orbitofrontal cortex Resting state fmri Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Tammo Viering Pieter J. Hoekstra Alexandra Philipsen Jilly Naaijen Andrea Dietrich Catharina A. Hartman Barbara Franke Jan K. Buitelaar Andrea Hildebrandt Christiane M. Thiel Carsten Gießing Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence
description	The course of attention deficit hyperactivity disorder (ADHD) from adolescence into adulthood shows large variations between individuals; nonetheless determinants of interindividual differences in the course are not well understood. A frequent problem in ADHD, associated with worse outcomes, is emotion dysregulation. We investigated whether emotion dysregulation and integration of emotion-related functional brain networks affect interindividual differences in ADHD severity change. ADHD severity and resting state neuroimaging data were measured in ADHD and unaffected individuals at two points during adolescence and young adulthood. Bivariate latent change score models were applied to investigate whether emotion dysregulation and network integration affect ADHD severity changes. Emotion dysregulation was gauged from questionnaire subscales for conduct problems, emotional problems and emotional lability. Better emotion regulation was associated with a better course of ADHD (104 participants, 44 females, age range: 12–27). Using graph analysis, we determined network integration of emotion-related functional brain networks. Network integration was measured by nodal efficiency, i.e., the average inverse path distance from one node to all other nodes. A pattern of low nodal efficiency of cortical regions associated with emotion processing and high nodal efficiency in subcortical areas and cortical areas involved in implicit emotion regulation predicted a better ADHD course. Larger nodal efficiency of the right orbitofrontal cortex was related to a better course of ADHD (99 participants, 42 females, age range: 10–29). We demonstrated that neural and behavioral covariates associated with emotion regulation affect the course of ADHD severity throughout adolescence and early adulthood beyond baseline effects of ADHD severity.
format	article
author	Tammo Viering Pieter J. Hoekstra Alexandra Philipsen Jilly Naaijen Andrea Dietrich Catharina A. Hartman Barbara Franke Jan K. Buitelaar Andrea Hildebrandt Christiane M. Thiel Carsten Gießing
author_facet	Tammo Viering Pieter J. Hoekstra Alexandra Philipsen Jilly Naaijen Andrea Dietrich Catharina A. Hartman Barbara Franke Jan K. Buitelaar Andrea Hildebrandt Christiane M. Thiel Carsten Gießing
author_sort	Tammo Viering
title	Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence
title_short	Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence
title_full	Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence
title_fullStr	Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence
title_full_unstemmed	Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence
title_sort	emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in adhd severity throughout late adolescence
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f11a2e296cf54b579607c452911bf0aa
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Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence

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