$Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up$
Código QR

Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up

Leopoldo Spadea, Giacomo Visioli, Davide Mastromarino, Shehani Alexander, Santino Pistella Eye Clinic, Policlinico Umberto 1, “Sapienza” University of Rome, Rome, ItalyCorrespondence: Leopoldo SpadeaHead Eye Clinic, Policlinico Umberto 1, “Sapienza” University of Rome, Via Benozzo Gozzoli 34, Rome,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Spadea L, Visioli G, Mastromarino D, Alexander S, Pistella S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	prk corneal aberrations keratoconus refraction corneal transplant Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f11a9683b54449598d6ed86e11c876af
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f11a9683b54449598d6ed86e11c876af
record_format	dspace
spelling	oai:doaj.org-article:f11a9683b54449598d6ed86e11c876af2021-12-02T17:28:50ZTopography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up1178-203Xhttps://doaj.org/article/f11a9683b54449598d6ed86e11c876af2021-09-01T00:00:00Zhttps://www.dovepress.com/topography-guided-trans-epithelial-no-touch-photorefractive-keratectom-peer-reviewed-fulltext-article-TCRMhttps://doaj.org/toc/1178-203XLeopoldo Spadea, Giacomo Visioli, Davide Mastromarino, Shehani Alexander, Santino Pistella Eye Clinic, Policlinico Umberto 1, “Sapienza” University of Rome, Rome, ItalyCorrespondence: Leopoldo SpadeaHead Eye Clinic, Policlinico Umberto 1, “Sapienza” University of Rome, Via Benozzo Gozzoli 34, Rome, 00142, ItalyTel +39 06 519 3220Fax +39 06 8865 7818Email leopoldo.spadea@uniroma1.itPurpose: To describe the efficacy and safety of topography-guided trans-epithelial no-touch photorefractive keratectomy (PRK) for the correction of highly irregular astigmatism after penetrating keratoplasty (PK).Patients and Methods: A prospective study was conducted on 12 eyes of 12 patients affected by highly irregular astigmatism after PK for keratoconus. Each patient underwent a single-step topography-guided trans-epithelial ablation (CIPTA® 2 software, iVis Technologies). Corneal topography data as well as uncorrected (UDVA) and corrected distance visual acuity (CDVA) and spherical equivalent (SEQ) were collected preoperatively (T0) and at 1 (T1), 3 (T2) and 12 (T3) months after surgery.Results: Mean UDVA and CDVA significantly improved, respectively, from 1.22± 0.17 and 0.18± 0.03LogMAR at T0 to 0.63± 0.17 (CI 95%, P< 0.001) and 0.04± 0.03LogMAR at T3 (CI 95%, P< 0.001). Mean SEQ significantly decreased from − 3.75± 1.32 to – 1.60± 1.32D (CI 95%, P< 0.02). Mean subjective refractive astigmatism (SRAST) and mean keratometry astigmatism (SimK) significantly decreased, respectively, from 7.83± 0.98 and 8.10± 1.48D to 2.83± 0.98 and 5.29± 1.48D (CI 95%, P< 0.001). Corneal Morphological Irregularity index (CMI) significantly decreased from 62.76± 7.26 μm to 23.24± 7.26 μm (CI 95%, P< 0.001). Apart from a single episode of graft rejection 5 days after ablation, successfully reverted with topical steroids, no other complications were noted. A mild corneal haze was observed in two eyes (16.7%) at 3 months post-PRK, and no regression was observed at 12 months.Conclusion: Our study demonstrates the safety and long-term effectiveness of a trans-epithelial topography-guided ablation in the treatment of post-PK highly irregular astigmatism.Keywords: PRK, corneal aberrations, keratoconus, refraction, corneal transplantSpadea LVisioli GMastromarino DAlexander SPistella SDove Medical Pressarticleprkcorneal aberrationskeratoconusrefractioncorneal transplantTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 1027-1035 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prk corneal aberrations keratoconus refraction corneal transplant Therapeutics. Pharmacology RM1-950
spellingShingle	prk corneal aberrations keratoconus refraction corneal transplant Therapeutics. Pharmacology RM1-950 Spadea L Visioli G Mastromarino D Alexander S Pistella S Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up
description	Leopoldo Spadea, Giacomo Visioli, Davide Mastromarino, Shehani Alexander, Santino Pistella Eye Clinic, Policlinico Umberto 1, “Sapienza” University of Rome, Rome, ItalyCorrespondence: Leopoldo SpadeaHead Eye Clinic, Policlinico Umberto 1, “Sapienza” University of Rome, Via Benozzo Gozzoli 34, Rome, 00142, ItalyTel +39 06 519 3220Fax +39 06 8865 7818Email leopoldo.spadea@uniroma1.itPurpose: To describe the efficacy and safety of topography-guided trans-epithelial no-touch photorefractive keratectomy (PRK) for the correction of highly irregular astigmatism after penetrating keratoplasty (PK).Patients and Methods: A prospective study was conducted on 12 eyes of 12 patients affected by highly irregular astigmatism after PK for keratoconus. Each patient underwent a single-step topography-guided trans-epithelial ablation (CIPTA® 2 software, iVis Technologies). Corneal topography data as well as uncorrected (UDVA) and corrected distance visual acuity (CDVA) and spherical equivalent (SEQ) were collected preoperatively (T0) and at 1 (T1), 3 (T2) and 12 (T3) months after surgery.Results: Mean UDVA and CDVA significantly improved, respectively, from 1.22± 0.17 and 0.18± 0.03LogMAR at T0 to 0.63± 0.17 (CI 95%, P< 0.001) and 0.04± 0.03LogMAR at T3 (CI 95%, P< 0.001). Mean SEQ significantly decreased from − 3.75± 1.32 to – 1.60± 1.32D (CI 95%, P< 0.02). Mean subjective refractive astigmatism (SRAST) and mean keratometry astigmatism (SimK) significantly decreased, respectively, from 7.83± 0.98 and 8.10± 1.48D to 2.83± 0.98 and 5.29± 1.48D (CI 95%, P< 0.001). Corneal Morphological Irregularity index (CMI) significantly decreased from 62.76± 7.26 μm to 23.24± 7.26 μm (CI 95%, P< 0.001). Apart from a single episode of graft rejection 5 days after ablation, successfully reverted with topical steroids, no other complications were noted. A mild corneal haze was observed in two eyes (16.7%) at 3 months post-PRK, and no regression was observed at 12 months.Conclusion: Our study demonstrates the safety and long-term effectiveness of a trans-epithelial topography-guided ablation in the treatment of post-PK highly irregular astigmatism.Keywords: PRK, corneal aberrations, keratoconus, refraction, corneal transplant
format	article
author	Spadea L Visioli G Mastromarino D Alexander S Pistella S
author_facet	Spadea L Visioli G Mastromarino D Alexander S Pistella S
author_sort	Spadea L
title	Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up
title_short	Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up
title_full	Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up
title_fullStr	Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up
title_full_unstemmed	Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up
title_sort	topography-guided trans-epithelial no-touch photorefractive keratectomy for high irregular astigmatism after penetrating keratoplasty: a prospective 12-months follow-up
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f11a9683b54449598d6ed86e11c876af
work_keys_str_mv	AT spadeal topographyguidedtransepithelialnotouchphotorefractivekeratectomyforhighirregularastigmatismafterpenetratingkeratoplastyaprospective12monthsfollowup AT visiolig topographyguidedtransepithelialnotouchphotorefractivekeratectomyforhighirregularastigmatismafterpenetratingkeratoplastyaprospective12monthsfollowup AT mastromarinod topographyguidedtransepithelialnotouchphotorefractivekeratectomyforhighirregularastigmatismafterpenetratingkeratoplastyaprospective12monthsfollowup AT alexanders topographyguidedtransepithelialnotouchphotorefractivekeratectomyforhighirregularastigmatismafterpenetratingkeratoplastyaprospective12monthsfollowup AT pistellas topographyguidedtransepithelialnotouchphotorefractivekeratectomyforhighirregularastigmatismafterpenetratingkeratoplastyaprospective12monthsfollowup
_version_	1718380765019897856

Topography-Guided Trans-Epithelial No-Touch Photorefractive Keratectomy for High Irregular Astigmatism After Penetrating Keratoplasty: A Prospective 12-Months Follow-Up

Ejemplares similares