PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes.

PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes.

<h4>Background</h4>PI3Kδ is a lipid kinase of the phosphoinositide 3-kinase class 1A family and involved in early signaling events of leukocytes regulating proliferation, differentiation and survival. Currently, several inhibitors of PI3Kδ are under investigation for the treatment of hem...

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Main Authors: Eva Maria Putz, Michaela Prchal-Murphy, Olivia Annabella Simma, Florian Forster, Xaver Koenig, Hannes Stockinger, Roland P Piekorz, Michael Freissmuth, Mathias Müller, Veronika Sexl, Eva Zebedin-Brandl
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/f11fad88bd3f492c80b004585328d4ba
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