Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

Ezh2 is an histone methyltransferase that catalyzes H3K27me3. Here the authors show that Ezh2 promotes T follicular helper (TFH) differentiation and helper activity, by cooperating with Tcf1 to activate Bcl6 transcription and epigenetically repressing p19Arf, an antagonist of Bcl6 function and TFH c...

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Autores principales:	Fengyin Li, Zhouhao Zeng, Shaojun Xing, Jodi A. Gullicksrud, Qiang Shan, Jinyong Choi, Vladimir P. Badovinac, Shane Crotty, Weiqun Peng, Hai-Hui Xue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1239f4303df4ca9b5410ccf3c44ff57
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spelling	oai:doaj.org-article:f1239f4303df4ca9b5410ccf3c44ff572021-12-02T17:32:16ZEzh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf10.1038/s41467-018-07853-z2041-1723https://doaj.org/article/f1239f4303df4ca9b5410ccf3c44ff572018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07853-zhttps://doaj.org/toc/2041-1723Ezh2 is an histone methyltransferase that catalyzes H3K27me3. Here the authors show that Ezh2 promotes T follicular helper (TFH) differentiation and helper activity, by cooperating with Tcf1 to activate Bcl6 transcription and epigenetically repressing p19Arf, an antagonist of Bcl6 function and TFH cell survival.Fengyin LiZhouhao ZengShaojun XingJodi A. GullicksrudQiang ShanJinyong ChoiVladimir P. BadovinacShane CrottyWeiqun PengHai-Hui XueNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fengyin Li Zhouhao Zeng Shaojun Xing Jodi A. Gullicksrud Qiang Shan Jinyong Choi Vladimir P. Badovinac Shane Crotty Weiqun Peng Hai-Hui Xue Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
description	Ezh2 is an histone methyltransferase that catalyzes H3K27me3. Here the authors show that Ezh2 promotes T follicular helper (TFH) differentiation and helper activity, by cooperating with Tcf1 to activate Bcl6 transcription and epigenetically repressing p19Arf, an antagonist of Bcl6 function and TFH cell survival.
format	article
author	Fengyin Li Zhouhao Zeng Shaojun Xing Jodi A. Gullicksrud Qiang Shan Jinyong Choi Vladimir P. Badovinac Shane Crotty Weiqun Peng Hai-Hui Xue
author_facet	Fengyin Li Zhouhao Zeng Shaojun Xing Jodi A. Gullicksrud Qiang Shan Jinyong Choi Vladimir P. Badovinac Shane Crotty Weiqun Peng Hai-Hui Xue
author_sort	Fengyin Li
title	Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
title_short	Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
title_full	Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
title_fullStr	Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
title_full_unstemmed	Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf
title_sort	ezh2 programs tfh differentiation by integrating phosphorylation-dependent activation of bcl6 and polycomb-dependent repression of p19arf
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f1239f4303df4ca9b5410ccf3c44ff57
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Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

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