Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

Ezh2 is an histone methyltransferase that catalyzes H3K27me3. Here the authors show that Ezh2 promotes T follicular helper (TFH) differentiation and helper activity, by cooperating with Tcf1 to activate Bcl6 transcription and epigenetically repressing p19Arf, an antagonist of Bcl6 function and TFH c...

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Autores principales: Fengyin Li, Zhouhao Zeng, Shaojun Xing, Jodi A. Gullicksrud, Qiang Shan, Jinyong Choi, Vladimir P. Badovinac, Shane Crotty, Weiqun Peng, Hai-Hui Xue
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/f1239f4303df4ca9b5410ccf3c44ff57
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