Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines

Chiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.

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Autores principales:	Dan Liu, Bowen Li, Jianzhong Chen, Ilya D. Gridnev, Deyue Yan, Wanbin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1244b61e228435dbc80c84960209471
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spelling	oai:doaj.org-article:f1244b61e228435dbc80c849602094712021-12-02T10:48:00ZNi-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines10.1038/s41467-020-19807-52041-1723https://doaj.org/article/f1244b61e228435dbc80c849602094712020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19807-5https://doaj.org/toc/2041-1723Chiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.Dan LiuBowen LiJianzhong ChenIlya D. GridnevDeyue YanWanbin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dan Liu Bowen Li Jianzhong Chen Ilya D. Gridnev Deyue Yan Wanbin Zhang Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
description	Chiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.
format	article
author	Dan Liu Bowen Li Jianzhong Chen Ilya D. Gridnev Deyue Yan Wanbin Zhang
author_facet	Dan Liu Bowen Li Jianzhong Chen Ilya D. Gridnev Deyue Yan Wanbin Zhang
author_sort	Dan Liu
title	Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_short	Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_full	Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_fullStr	Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_full_unstemmed	Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_sort	ni-catalyzed asymmetric hydrogenation of n-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f1244b61e228435dbc80c84960209471
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Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines

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