Human endogenous retroviruses in development and disease

Human endogenous retroviruses (HERVs) represent ∼8% of human genome, deriving from exogenous retroviral infections of germ line cells occurred millions of years ago and being inherited by the offspring in a Mendelian fashion. Most of HERVs are nonprotein-coding because of the accumulation of mutatio...

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Autores principales:	Jian Mao, Qian Zhang, Yu-Sheng Cong
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Human endogenous retroviruses (HERVs) Embryonic development and pluripotency Cancer Aging Neurodegenerative diseases Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/f125f24d72ce4300b6716fb98a4095d4
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spelling	oai:doaj.org-article:f125f24d72ce4300b6716fb98a4095d42021-11-14T04:31:40ZHuman endogenous retroviruses in development and disease2001-037010.1016/j.csbj.2021.10.037https://doaj.org/article/f125f24d72ce4300b6716fb98a4095d42021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2001037021004591https://doaj.org/toc/2001-0370Human endogenous retroviruses (HERVs) represent ∼8% of human genome, deriving from exogenous retroviral infections of germ line cells occurred millions of years ago and being inherited by the offspring in a Mendelian fashion. Most of HERVs are nonprotein-coding because of the accumulation of mutations, insertions, deletions, and/or truncations. It has been long thought that HERVs were “junk DNA”. However, it is now known that HERVs are involved in various biological processes through encoding proteins, acting as promoters/enhancers, or lncRNAs to affect human health and disease. In this review, we summarized recent findings about HERVs, with implications in embryonic development, pluripotency, cancer, aging, and neurodegenerative diseases.Jian MaoQian ZhangYu-Sheng CongElsevierarticleHuman endogenous retroviruses (HERVs)Embryonic development and pluripotencyCancerAgingNeurodegenerative diseasesBiotechnologyTP248.13-248.65ENComputational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5978-5986 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Human endogenous retroviruses (HERVs) Embryonic development and pluripotency Cancer Aging Neurodegenerative diseases Biotechnology TP248.13-248.65
spellingShingle	Human endogenous retroviruses (HERVs) Embryonic development and pluripotency Cancer Aging Neurodegenerative diseases Biotechnology TP248.13-248.65 Jian Mao Qian Zhang Yu-Sheng Cong Human endogenous retroviruses in development and disease
description	Human endogenous retroviruses (HERVs) represent ∼8% of human genome, deriving from exogenous retroviral infections of germ line cells occurred millions of years ago and being inherited by the offspring in a Mendelian fashion. Most of HERVs are nonprotein-coding because of the accumulation of mutations, insertions, deletions, and/or truncations. It has been long thought that HERVs were “junk DNA”. However, it is now known that HERVs are involved in various biological processes through encoding proteins, acting as promoters/enhancers, or lncRNAs to affect human health and disease. In this review, we summarized recent findings about HERVs, with implications in embryonic development, pluripotency, cancer, aging, and neurodegenerative diseases.
format	article
author	Jian Mao Qian Zhang Yu-Sheng Cong
author_facet	Jian Mao Qian Zhang Yu-Sheng Cong
author_sort	Jian Mao
title	Human endogenous retroviruses in development and disease
title_short	Human endogenous retroviruses in development and disease
title_full	Human endogenous retroviruses in development and disease
title_fullStr	Human endogenous retroviruses in development and disease
title_full_unstemmed	Human endogenous retroviruses in development and disease
title_sort	human endogenous retroviruses in development and disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f125f24d72ce4300b6716fb98a4095d4
work_keys_str_mv	AT jianmao humanendogenousretrovirusesindevelopmentanddisease AT qianzhang humanendogenousretrovirusesindevelopmentanddisease AT yushengcong humanendogenousretrovirusesindevelopmentanddisease
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Human endogenous retroviruses in development and disease

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