Efficacy of induction regimens for cryptococcal meningitis in HIV-infected adults: a systematic review and network meta-analysis
Abstract Cryptococcal meningitis (CM) is the most fatal adult meningitis in patients with human immunodeficiency virus (HIV). There is no conclusive evidence for the superiority of 1-week amphotericin B deoxycholate (AmphB) + flucytosine (5-FC) regimen over other antifungals in the management of HIV...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f126a7ac413343f0884a2b128a58f641 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f126a7ac413343f0884a2b128a58f641 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f126a7ac413343f0884a2b128a58f6412021-12-02T16:45:22ZEfficacy of induction regimens for cryptococcal meningitis in HIV-infected adults: a systematic review and network meta-analysis10.1038/s41598-021-87726-62045-2322https://doaj.org/article/f126a7ac413343f0884a2b128a58f6412021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87726-6https://doaj.org/toc/2045-2322Abstract Cryptococcal meningitis (CM) is the most fatal adult meningitis in patients with human immunodeficiency virus (HIV). There is no conclusive evidence for the superiority of 1-week amphotericin B deoxycholate (AmphB) + flucytosine (5-FC) regimen over other antifungals in the management of HIV patients with CM (HIV–CM patients). We aimed to evaluate the differences in efficacy and tolerability of different antifungal agents in HIV–CM patients by conducting a current network meta-analysis NMA. Overall, 19 randomized controlled trials were included with 2642 participants. A regimen indicated a possibly lower early mortality rate, namely, AmphB + 5-FC + Azole (OR = 1.1E−12, 95% CIs = 1.3E−41 to 0.06) comparing to AmphB + 5-FC. The current NMA provides evidence that AmphB + 5-FC + Azole are superior to all the investigated treatments for induction regimen in HIV–CM patients.Chang-Hua ChenHua LiHsien-Meng ChenYu-Min ChenYu-Jun ChangPao-Yen LinChih-Wei HsuPing-Tao TsengKai-Huang LinYu-Kang TuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Chang-Hua Chen Hua Li Hsien-Meng Chen Yu-Min Chen Yu-Jun Chang Pao-Yen Lin Chih-Wei Hsu Ping-Tao Tseng Kai-Huang Lin Yu-Kang Tu Efficacy of induction regimens for cryptococcal meningitis in HIV-infected adults: a systematic review and network meta-analysis |
| description |
Abstract Cryptococcal meningitis (CM) is the most fatal adult meningitis in patients with human immunodeficiency virus (HIV). There is no conclusive evidence for the superiority of 1-week amphotericin B deoxycholate (AmphB) + flucytosine (5-FC) regimen over other antifungals in the management of HIV patients with CM (HIV–CM patients). We aimed to evaluate the differences in efficacy and tolerability of different antifungal agents in HIV–CM patients by conducting a current network meta-analysis NMA. Overall, 19 randomized controlled trials were included with 2642 participants. A regimen indicated a possibly lower early mortality rate, namely, AmphB + 5-FC + Azole (OR = 1.1E−12, 95% CIs = 1.3E−41 to 0.06) comparing to AmphB + 5-FC. The current NMA provides evidence that AmphB + 5-FC + Azole are superior to all the investigated treatments for induction regimen in HIV–CM patients. |
| format |
article |
| author |
Chang-Hua Chen Hua Li Hsien-Meng Chen Yu-Min Chen Yu-Jun Chang Pao-Yen Lin Chih-Wei Hsu Ping-Tao Tseng Kai-Huang Lin Yu-Kang Tu |
| author_facet |
Chang-Hua Chen Hua Li Hsien-Meng Chen Yu-Min Chen Yu-Jun Chang Pao-Yen Lin Chih-Wei Hsu Ping-Tao Tseng Kai-Huang Lin Yu-Kang Tu |
| author_sort |
Chang-Hua Chen |
| title |
Efficacy of induction regimens for cryptococcal meningitis in HIV-infected adults: a systematic review and network meta-analysis |
| title_short |
Efficacy of induction regimens for cryptococcal meningitis in HIV-infected adults: a systematic review and network meta-analysis |
| title_full |
Efficacy of induction regimens for cryptococcal meningitis in HIV-infected adults: a systematic review and network meta-analysis |
| title_fullStr |
Efficacy of induction regimens for cryptococcal meningitis in HIV-infected adults: a systematic review and network meta-analysis |
| title_full_unstemmed |
Efficacy of induction regimens for cryptococcal meningitis in HIV-infected adults: a systematic review and network meta-analysis |
| title_sort |
efficacy of induction regimens for cryptococcal meningitis in hiv-infected adults: a systematic review and network meta-analysis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/f126a7ac413343f0884a2b128a58f641 |
| work_keys_str_mv |
AT changhuachen efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis AT huali efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis AT hsienmengchen efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis AT yuminchen efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis AT yujunchang efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis AT paoyenlin efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis AT chihweihsu efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis AT pingtaotseng efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis AT kaihuanglin efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis AT yukangtu efficacyofinductionregimensforcryptococcalmeningitisinhivinfectedadultsasystematicreviewandnetworkmetaanalysis |
| _version_ |
1718383490233270272 |