Microtubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer

Mitochondria constitute an ever-reorganizing dynamic network that plays a key role in several fundamental cellular functions, including the regulation of metabolism, energy production, calcium homeostasis, production of reactive oxygen species, and programmed cell death. Each of these activities can...

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Autores principales:	Rosa Vona, Anna Maria Mileo, Paola Matarrese
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microtubules mitochondria dynamics mitophagy cancer bioenergetics tunneling nanotubes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f127aa198be14dfea68f24a4a4853804
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spelling	oai:doaj.org-article:f127aa198be14dfea68f24a4a48538042021-11-25T17:04:19ZMicrotubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer10.3390/cancers132258122072-6694https://doaj.org/article/f127aa198be14dfea68f24a4a48538042021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5812https://doaj.org/toc/2072-6694Mitochondria constitute an ever-reorganizing dynamic network that plays a key role in several fundamental cellular functions, including the regulation of metabolism, energy production, calcium homeostasis, production of reactive oxygen species, and programmed cell death. Each of these activities can be found to be impaired in cancer cells. It has been reported that mitochondrial dynamics are actively involved in both tumorigenesis and metabolic plasticity, allowing cancer cells to adapt to unfavorable environmental conditions and, thus, contributing to tumor progression. The mitochondrial dynamics include fusion, fragmentation, intracellular trafficking responsible for redistributing the organelle within the cell, biogenesis, and mitophagy. Although the mitochondrial dynamics are driven by the cytoskeleton—particularly by the microtubules and the microtubule-associated motor proteins dynein and kinesin—the molecular mechanisms regulating these complex processes are not yet fully understood. More recently, an exchange of mitochondria between stromal and cancer cells has also been described. The advantage of mitochondrial transfer in tumor cells results in benefits to cell survival, proliferation, and spreading. Therefore, understanding the molecular mechanisms that regulate mitochondrial trafficking can potentially be important for identifying new molecular targets in cancer therapy to interfere specifically with tumor dissemination processes.Rosa VonaAnna Maria MileoPaola MatarreseMDPI AGarticlemicrotubulesmitochondria dynamicsmitophagycancer bioenergeticstunneling nanotubesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5812, p 5812 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microtubules mitochondria dynamics mitophagy cancer bioenergetics tunneling nanotubes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	microtubules mitochondria dynamics mitophagy cancer bioenergetics tunneling nanotubes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Rosa Vona Anna Maria Mileo Paola Matarrese Microtubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer
description	Mitochondria constitute an ever-reorganizing dynamic network that plays a key role in several fundamental cellular functions, including the regulation of metabolism, energy production, calcium homeostasis, production of reactive oxygen species, and programmed cell death. Each of these activities can be found to be impaired in cancer cells. It has been reported that mitochondrial dynamics are actively involved in both tumorigenesis and metabolic plasticity, allowing cancer cells to adapt to unfavorable environmental conditions and, thus, contributing to tumor progression. The mitochondrial dynamics include fusion, fragmentation, intracellular trafficking responsible for redistributing the organelle within the cell, biogenesis, and mitophagy. Although the mitochondrial dynamics are driven by the cytoskeleton—particularly by the microtubules and the microtubule-associated motor proteins dynein and kinesin—the molecular mechanisms regulating these complex processes are not yet fully understood. More recently, an exchange of mitochondria between stromal and cancer cells has also been described. The advantage of mitochondrial transfer in tumor cells results in benefits to cell survival, proliferation, and spreading. Therefore, understanding the molecular mechanisms that regulate mitochondrial trafficking can potentially be important for identifying new molecular targets in cancer therapy to interfere specifically with tumor dissemination processes.
format	article
author	Rosa Vona Anna Maria Mileo Paola Matarrese
author_facet	Rosa Vona Anna Maria Mileo Paola Matarrese
author_sort	Rosa Vona
title	Microtubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer
title_short	Microtubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer
title_full	Microtubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer
title_fullStr	Microtubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer
title_full_unstemmed	Microtubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer
title_sort	microtubule-based mitochondrial dynamics as a valuable therapeutic target in cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f127aa198be14dfea68f24a4a4853804
work_keys_str_mv	AT rosavona microtubulebasedmitochondrialdynamicsasavaluabletherapeutictargetincancer AT annamariamileo microtubulebasedmitochondrialdynamicsasavaluabletherapeutictargetincancer AT paolamatarrese microtubulebasedmitochondrialdynamicsasavaluabletherapeutictargetincancer
_version_	1718412812311592960

Microtubule-Based Mitochondrial Dynamics as a Valuable Therapeutic Target in Cancer

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